July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Multimodal imaging of the initial stages of diabetic retinopathy. Different disease pathways in different patients.
Author Affiliations & Notes
  • Dalila Alves
    4C, AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Inês \ Marques
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Torcato Santos
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Luis Mendes
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Ana Rita Santos
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Conceição Lobo
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
    Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Mary K Durbin
    R & D, Carl Zeiss Meditec, Inc, California, United States
  • Jose G Cunha-Vaz
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
    Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Footnotes
    Commercial Relationships   Dalila Alves, None; Inês Marques, None; Torcato Santos, None; Luis Mendes, None; Ana Rita Santos, None; Conceição Lobo, None; Mary Durbin, Carl Zeiss Meditec, Inc (E); Jose Cunha-Vaz, Carl Zeiss Meditec, Inc (F)
  • Footnotes
    Support  Clinical Research Agreement - Carl Zeiss Meditec
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3022. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Dalila Alves, Inês \ Marques, Torcato Santos, Luis Mendes, Ana Rita Santos, Conceição Lobo, Mary K Durbin, Jose G Cunha-Vaz; Multimodal imaging of the initial stages of diabetic retinopathy. Different disease pathways in different patients.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3022. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To evaluate the prevalence of different disease pathways (ischemia, neurodegeneration and edema) in the initial stages of diabetic retinopathy (DR).

Methods : In this retrospective cross-sectional study, eyes were grouped by DR severity using the 7-field ETDRS protocol (levels 10-20, 35 and 43-47). Neurodegeneration was identified by thinning of the retinal nerve fiber layer (RNFL) and/or ganglion cell layer (GCL). Edema was identified by thickening of the inner nuclear layer (INL), outer plexiform layer (OPL), or full retina. Ischemia was identified by metrics of retinal vessel density.

Results :
142 eyes from 142 patients (28% women) aged 52-88 years were imaged. Loss of vessel density (ischemia) was significantly different between ETDRS groups (p<0.020). On multivariate regression analysis, it remained significantly different between stages of the disease and showed associations with age (p<0.001), gender (p=0.028) and metabolic control (p=0.034). No significant differences between ETDRS groups were found in retinal thinning (neurodegeneration) or retinal thickness (edema).

Conclusions : Eyes with the same ETDRS retinopathy grading from different diabetic patients show that the prevalence of different disease pathways varies between patients even within the same severity group. Ischemia (loss of vessel density) is the only disease pathway that shows correlation with retinopathy severity and metabolic control.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×