July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Wavelength Specificity of Violet Light on Suppressing Refractive Change and Axial Elongation in A Murine Model of Lens-induced Myopia
Author Affiliations & Notes
  • Xiaoyan Jiang
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Toshihide Kurihara
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Kiwako Mori
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Shin-ichi Ikeda
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Hidemasa Torii
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Kazuo Tsubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Xiaoyan Jiang, Keio University (P); Toshihide Kurihara, Keio University (P); Kiwako Mori, None; Shin-ichi Ikeda, None; Hidemasa Torii, None; Kazuo Tsubota, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3153. doi:https://doi.org/
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      Xiaoyan Jiang, Toshihide Kurihara, Kiwako Mori, Shin-ichi Ikeda, Hidemasa Torii, Kazuo Tsubota; Wavelength Specificity of Violet Light on Suppressing Refractive Change and Axial Elongation in A Murine Model of Lens-induced Myopia. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3153. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We reported that violet light (VL, 360nm-400nm) may prevent myopia progression in mice, chicks and human beings (Torii et al. EBioMedicine. 2017; Torii et al. Sci Rep. 2017; Kurihara et al. ARVO. 2018). Here we compared the influence of VL exposure on myopia progression with blue light (BL, 440nm~480nm), green light (GL, 500nm~540nm), and red light (RL, 610nm~650nm) in a murine model of lens-induced myopia (LIM).

Methods : For LIM, twenty of 3-week-old wild-type C57BL/6J mice were attached with 0 diopter (D) lenses on the left eyes and -20 D lenses on the right eyes by mounting a frame on their skull using a self-cure dental adhesive system. Mice were then divided randomly into 5 groups (n=4 each) and kept under different light conditions for 1 week: Control group, VL group, BL group, GL group and RL group. All groups were exposed to white fluorescent lamp light (50 lux) as background light from 08:00 to 20:00. Same strength (400μw/cm2) of VL, BL, GL or RL irradiation was added from 17:00 to 20:00 every day respectively in each group. The control group was exposed to the background light only. The myopic shifts were evaluated by measuring intraocular changes of refractive states and axial lengths before and after the one-week light exposure with LIM induction.

Results : For interocular refractive changes, compared with the control group (-24.4±6.7D), VL significantly suppressed myopic shift (-13.4±4.2D, p<0.05), while BL (-14.2±11.9D), GL (-33.1±8.5D), and RL (-19.6±4.9D) had no significant effect. For interocular axial length changes, compared with the control group (0.049±0.024mm), VL (0.002±0.020mm, P<0.05) and BL (0.010±0.012mm, P<0.05) significantly suppressed axial elongation while GL (0.040±0.018mm) and RL (0.030±0.027mm) had no significant effect.

Conclusions : Among the four wavelengths of light tested, only VL can suppress myopia progression in both refraction and axial length in LIM mice.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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