July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Aqueous Humor and Serum 25-Hydroxyvitamin D Levels in Patients with Cataracts
Author Affiliations & Notes
  • Woong-Sun Yoo
    Department of ophthalmology, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)
  • Min-Chul Cho
    Gyeongsang National University Hospital, Korea (the Republic of)
  • Gyu-Nam Kim
    Department of ophthalmology, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)
  • Hyuna Kim
    Department of ophthalmology, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)
  • Seong wook Seo
    Department of ophthalmology, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)
  • Seong-Jae Kim
    Department of ophthalmology, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Woong-Sun Yoo, None; Min-Chul Cho, None; Gyu-Nam Kim, None; Hyuna Kim, None; Seong wook Seo, None; Seong-Jae Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3187. doi:
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      Woong-Sun Yoo, Min-Chul Cho, Gyu-Nam Kim, Hyuna Kim, Seong wook Seo, Seong-Jae Kim; Aqueous Humor and Serum 25-Hydroxyvitamin D Levels in Patients with Cataracts. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3187.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate whether 25-hydroxyvitamin D (25(OH)D) concentrations in aqueous humor correlated with serum 25(OH)D concentrations and whether vitamin D concentrations in aqueous humor were associated with cataract.To investigate whether 25-hydroxyvitamin D (25(OH)D) concentrations in aqueous humor correlated with serum 25(OH)D concentrations and whether vitamin D concentrations in aqueous humor were associated with cataract.

Methods : 25(OH)D was measured in aqueous humor and serum specimens collected from all patients, and their correlation was analyzed statistically. Clinical and laboratory data, including the results of ophthalmologic examinations, were compared in the two groups of cataract patients.

Results : 25(OH)D concentrations in aqueous humor and serum did not show significant correlation (P=0.381). 25(OH)D concentration in aqueous humor was significantly higher in patients with diabetic than senile cataract (P=0.006). Multivariate logistic regression analysis found that the adjusted OR for diabetic cataract for the highest compared with the lowest quartile of 25(OH)D concentration in aqueous humor was 4.36 ng/ml (95% confidence interval (CI) = 1.33–14.34 ng/ml; P=0.015). Multivariate linear regression analysis showed that 25(OH)D concentration in aqueous humor was 2.68 ng/ml (95% CI: 0.34–5.01 ng/ml; P=0.025) higher in patients with diabetic than senile cataract.

Conclusions : 25(OH) concentrations in aqueous humor and serum did not correlate with each other. Higher 25(OH)D level in aqueous humor was associated with diabetic cataract. These findings suggest that studies of vitamin D levels in ocular conditions should consider measuring vitamin D levels in aqueous humor.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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