Abstract
Purpose :
To investigate whether 25-hydroxyvitamin D (25(OH)D) concentrations in aqueous humor correlated with serum 25(OH)D concentrations and whether vitamin D concentrations in aqueous humor were associated with cataract.To investigate whether 25-hydroxyvitamin D (25(OH)D) concentrations in aqueous humor correlated with serum 25(OH)D concentrations and whether vitamin D concentrations in aqueous humor were associated with cataract.
Methods :
25(OH)D was measured in aqueous humor and serum specimens collected from all patients, and their correlation was analyzed statistically. Clinical and laboratory data, including the results of ophthalmologic examinations, were compared in the two groups of cataract patients.
Results :
25(OH)D concentrations in aqueous humor and serum did not show significant correlation (P=0.381). 25(OH)D concentration in aqueous humor was significantly higher in patients with diabetic than senile cataract (P=0.006). Multivariate logistic regression analysis found that the adjusted OR for diabetic cataract for the highest compared with the lowest quartile of 25(OH)D concentration in aqueous humor was 4.36 ng/ml (95% confidence interval (CI) = 1.33–14.34 ng/ml; P=0.015). Multivariate linear regression analysis showed that 25(OH)D concentration in aqueous humor was 2.68 ng/ml (95% CI: 0.34–5.01 ng/ml; P=0.025) higher in patients with diabetic than senile cataract.
Conclusions :
25(OH) concentrations in aqueous humor and serum did not correlate with each other. Higher 25(OH)D level in aqueous humor was associated with diabetic cataract. These findings suggest that studies of vitamin D levels in ocular conditions should consider measuring vitamin D levels in aqueous humor.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.