July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Evaluating the Short-Term Effects on Semi-automated Aqueous Flare Assessment After Fundus Fluorescein Angiography Imaging
Author Affiliations & Notes
  • Nam V Nguyen
    Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, United States
    Ocular Imaging Research and Reading Center, Menlo Park, California, United States
  • Muhammad Sohail Halim
    Department of Ophthalmology, Byers Eye Institute Stanford University, Palo Alto, California, United States
  • Muhammad Hassan
    Department of Ophthalmology, Byers Eye Institute Stanford University, Palo Alto, California, United States
  • Asadu Segawa
    Department of Ophthalmology, Gazi University, Ankara, Turkey
  • Mestan Ertop
    Department of Ophthalmology, Gazi University, Ankara, Turkey
  • Zeynep Aktas
    Department of Ophthalmology, Gazi University, Ankara, Turkey
  • Sengul Ozdek
    Department of Ophthalmology, Gazi University, Ankara, Turkey
  • Gokhan Gurelik
    Department of Ophthalmology, Gazi University, Ankara, Turkey
  • Anh Ngoc Tram Tran
    Department of Ophthalmology, Byers Eye Institute Stanford University, Palo Alto, California, United States
  • Sarakshi Mahajan
    Department of Ophthalmology, Byers Eye Institute Stanford University, Palo Alto, California, United States
  • Rubbia Afridi
    Department of Ophthalmology, Byers Eye Institute Stanford University, Palo Alto, California, United States
  • Mohamed A Ibrahim
    Ocular Imaging Research and Reading Center, Menlo Park, California, United States
  • Yasir Jamal Sepah
    Department of Ophthalmology, Byers Eye Institute Stanford University, Palo Alto, California, United States
  • Quan Dong Nguyen
    Department of Ophthalmology, Byers Eye Institute Stanford University, Palo Alto, California, United States
  • Murat Hasanreisoglu
    Department of Ophthalmology, Byers Eye Institute Stanford University, Palo Alto, California, United States
    Department of Ophthalmology, Gazi University, Ankara, Turkey
  • Footnotes
    Commercial Relationships   Nam Nguyen, None; Muhammad Sohail Halim, None; Muhammad Hassan, None; Asadu Segawa, None; Mestan Ertop, None; Zeynep Aktas, None; Sengul Ozdek, None; Gokhan Gurelik, None; Anh Tran, None; Sarakshi Mahajan, None; Rubbia Afridi, None; Mohamed Ibrahim, None; Yasir Jamal Sepah, None; Quan Nguyen, None; Murat Hasanreisoglu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3192. doi:
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      Nam V Nguyen, Muhammad Sohail Halim, Muhammad Hassan, Asadu Segawa, Mestan Ertop, Zeynep Aktas, Sengul Ozdek, Gokhan Gurelik, Anh Ngoc Tram Tran, Sarakshi Mahajan, Rubbia Afridi, Mohamed A Ibrahim, Yasir Jamal Sepah, Quan Dong Nguyen, Murat Hasanreisoglu; Evaluating the Short-Term Effects on Semi-automated Aqueous Flare Assessment After Fundus Fluorescein Angiography Imaging. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3192.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the change of aqueous flare values at 30 mins and 4 hours after fundus fluorescein angiography (FFA) imaging session.

Methods : In this prospective study, patients were enrolled from a uveitis clinic at Gazi University (Ankara, Turkey). All patients initially underwent a dilated (cyclopentolate 1% and phenylephrine 2.5%) ophthalmological examination where the physician assessed the grade of aqueous flare. Patients, who were scheduled to have fluorescein angiography imaging, were asked to participate in the study; consent was obtained. Thirty minutes before the FFA imaging session, a masked operator performed aqueous flare measurement on the patients using the laser flare meter (Kowa FM-700). The same operator also performed aqueous flare measurement 30 minutes and 4 hours after the FFA imaging session. The mean flare values were obtained at the three time points. The outliers for measured flare values were removed. Student paired t-test analysis was performed using Stata, version 15.1 (Stata Corp LLC, College Station, Texas USA); p-value <0.05 was deemed significant.

Results : Fourteen (14) patients (28 eyes) were included in the study. Four eyes were excluded due to extreme values; 24 eyes were analyzed. At baseline, the mean age of patients was 32.21 years, and 6 patients (43%) were female. Among 14 patients, 5 were diagnosed with pars planitis, 3 anterior uveitis, 4 posterior uveitis and 2 others. The mean intraocular pressure (IOP) at baseline was 13.86 ± 2.01 (mmHg). The mean laser flare values (±SE) were 10.05 ± 1.52, 9.21 ± 1.43, and 9.27 ± 1.47 (photon counts/millisecond) for 30 mins before, 30 mins after, and 4 hours after the FFA imaging section, respectively. The difference between laser flare measurement 30-min before and 30-min after was statistically significant (p-value=0.03). However, the difference between 30-min before and 4-hour after was not statistically significant (p-value=0.10).

Conclusions : Administration of fluorescein does not increase flare values. During FFA, laser flare values decreased in the early period after fluorescein administration. However, the effect on flare seems to normalize over time.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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