July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Corneal reinnervation after corneal neurotization using a great auricular nerve graft: an in vivo confocal microscopy study
Author Affiliations & Notes
  • Nacim Bouheraoua
    ophthalmology, Quinze national ophthalmology center, Paris, France
  • Ora Levy
    ophthalmology, Quinze national ophthalmology center, Paris, France
  • Isabelle Goemaere
    ophthalmology, Quinze national ophthalmology center, Paris, France
  • Vincent Borderie
    ophthalmology, Quinze national ophthalmology center, Paris, France
  • Laurent Laroche
    ophthalmology, Quinze national ophthalmology center, Paris, France
  • Hakim Benkhatar
    ophthalmology, Quinze national ophthalmology center, Paris, France
  • Footnotes
    Commercial Relationships   Nacim Bouheraoua, None; Ora Levy, None; Isabelle Goemaere, None; Vincent Borderie, None; Laurent Laroche, None; Hakim Benkhatar, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3237. doi:
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      Nacim Bouheraoua, Ora Levy, Isabelle Goemaere, Vincent Borderie, Laurent Laroche, Hakim Benkhatar; Corneal reinnervation after corneal neurotization using a great auricular nerve graft: an in vivo confocal microscopy study . Invest. Ophthalmol. Vis. Sci. 2019;60(9):3237.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess corneal sensation and reinnervation by esthesiometry and confocal microscopy after corneal neurotization to treat neurotrophic keratopathy in a 24-months follow-up.

Methods : Corneal neurotization was successfully achieved with thegreat auricular nerve in 10 patients. Cochet-Bonnet esthesiometry and in vivo confocal microscopy were performed before and after corneal neurotization to follow corneal sensation recovery and corneal reinnervation respectively.

Results : Neurotrophic keratopathies were the result of surgically treated meningioma or neurinoma. Before surgery corneal sensation and corneal innervation were absent. Six months after surgery, confocal microscopy confirmed regrowth of a high number of nerve fibers in the subepithelial space of the cornea. Nine months after surgery, we observed a recovery of corneal sensation.

Conclusions : The use of the great auricular nerve for corneal neurotization may be relevant because of its low associated morbidity and anatomical proximity. Confocal microscopy proved the corneal reinnervation. Corneal neurotization allows reinnervation of the cornea and recovery of ocular sensation and had opened a new era on the management of neurotrophic keratitis.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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