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Martine J Jager; Macrophages and eye diseases in the elderly.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3266.
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© ARVO (1962-2015); The Authors (2016-present)
Presentation Description :
During aging, several changes occur in the innate immune system. While in the young, M1 macrophages are essential in the defense against infectious agents, in the elderly, pro-angiogenic M2 macrophages play an important role. Such macrophages are involved in age-related macualr degeneration and in the development of uveal melanoma. In a third age-related disease, glaucoma, early pressure-induced damage leads to an influx of macrophages and a subsequent induction of intraocular inflammation. Overall, the innate immune system plays plan important role in the development of a wide range of age-related diseases.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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