July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Macrophages and eye diseases in the elderly.
Author Affiliations & Notes
  • Martine J Jager
    Ophthalmology, Leiden University Med Center, Leiden, Netherlands
  • Footnotes
    Commercial Relationships   Martine Jager, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3266. doi:
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      Martine J Jager; Macrophages and eye diseases in the elderly.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3266.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description : During aging, several changes occur in the innate immune system. While in the young, M1 macrophages are essential in the defense against infectious agents, in the elderly, pro-angiogenic M2 macrophages play an important role. Such macrophages are involved in age-related macualr degeneration and in the development of uveal melanoma. In a third age-related disease, glaucoma, early pressure-induced damage leads to an influx of macrophages and a subsequent induction of intraocular inflammation. Overall, the innate immune system plays plan important role in the development of a wide range of age-related diseases.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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