July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Ocular immune privilege programs monocytes to mediate innate memory-tolerance
Author Affiliations & Notes
  • Andrew W Taylor
    Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Andrew Taylor, Mallinckrodt Pharmaceuticals, Inc. (C), Palatin Technologies, Inc. (F), Palatin Technologies, Inc. (C)
  • Footnotes
    Support  Grants from NIH/NEI EY025961, and the Massachusetts Lions Eye Research Foundation
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3267. doi:
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    • Get Citation

      Andrew W Taylor; Ocular immune privilege programs monocytes to mediate innate memory-tolerance. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3267.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description : Retinal pigment epithelial cells (RPE) are a source of soluble molecules that can select and program macrophages to promote immune tolerance and suppress inflammation. This has suggested that ocular immune privilege has a mechanism to select for macrophages programmed to have memory-tolerance. This talk will present the experimental examples of how the RPE select and induce macrophages to act as suppressor/tolerogenic APC, and as suppressors of inflammation.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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