Abstract
Presentation Description :
The organization of resident innate immune cells in the retina is highly structured and stereotypical with respect to their distribution, density, and morphology. These organized features are likely determine how these cells interact with other retinal cell types and influence how they exert their functions under healthy and injured conditions. When this overall organization is perturbed by cellular loss, immune triggers, or breakdown in retinal barriers, homeostatic mechanisms are induced to restore immune equilibrium and reconstitute the organization of innate immune cells in the retina. We show examples of how microglia and monocytes contribute to restoring this homeostasis and discuss mechanisms of regulation and functional implications.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.