July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography.
Author Affiliations & Notes
  • Giovanni Gregori
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Fang Zheng
    Ophthalmology, Second Affiliated Hospital of Zhejiang University, Hangzhou, China
  • Qinqin Zhang
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Yingying Shi
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • jonathan russell
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • James Banta
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Zhongdi Chu
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Hao Zhou
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Nimesh Patel
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • William Feuer
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Mary K Durbin
    Carl Zeiss Meditec, Dublin, California, United States
  • Luis De Sisternes
    Carl Zeiss Meditec, Dublin, California, United States
  • Ruikang K Wang
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Philip J. Rosenfeld
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Giovanni Gregori, Carl Zeiss Meditec (F); Fang Zheng, None; Qinqin Zhang, None; Yingying Shi, None; jonathan russell, None; James Banta, None; Zhongdi Chu, None; Hao Zhou, None; Nimesh Patel, None; William Feuer, None; Mary Durbin, Carl Zeiss Meditec (E); Luis De Sisternes, Carl Zeiss Meditec (E); Ruikang Wang, Carl Zeiss Meditec (C), Carl Zeiss Meditec (P); Philip Rosenfeld, Carl Zeiss Meditec (F), Carl Zeiss Meditec (C)
  • Footnotes
    Support  Research Grant from Carl Zeiss Meditec
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3282. doi:
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      Giovanni Gregori, Fang Zheng, Qinqin Zhang, Yingying Shi, jonathan russell, James Banta, Zhongdi Chu, Hao Zhou, Nimesh Patel, William Feuer, Mary K Durbin, Luis De Sisternes, Ruikang K Wang, Philip J. Rosenfeld; Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3282.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Swept source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes.

Methods : Subjects with normal eyes were imaged using a 100-kHz SS-OCTA instrument (PLEXÒ Elite 9000, Carl Zeiss Meditec). Both 3x3 mm and 6x6 mm scans were acquired. Visualization of the CC and quantification of FDs were obtained using a previously validated algorithm. The percentage of FDs (FD%) in the central 1 mm circle (C1), 1.5 mm rim (R1.5), and 2.5 mm circle (C2.5) from the 3x3 mm and 6x6 mm scans and FD% in the 2.5 mm rim (R2.5) and 5 mm circle (C5) from the 6x6 mm scans were measured and correlated with age and axial length.

Results : A total of 164 eyes from 164 subjects were enrolled, with at least 10 subjects from each decade of life. Mean axial length was 23.80 ± 1.0 mm. Fifty-six percent of the subjects were women. No meaningful correlations were found between FD% and axial length (|r| < 0.30). Both the 3x3 mm and 6x6 mm scans provided comparable measurements of the FD% within C1, R1.5, and C2.5 (all r > 0.70). FD% in all fields increased with increasing age (all r > 0.50; all P < 0.001); however, the greatest increases were found in the central macula C1 regions and the smallest increases in the peripheral macula R2.5 regions.

Conclusions : In normal aging, the FD% increased with age across the central 5 mm of the macula, but the greatest increase was found in the central 1 mm macular region. Future studies of the CC need to consider these age-dependent CC changes when determining if changes in the CC are related to aging or disease.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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