July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Can manipulation of the retinal ON- OFF-pathways prevent myopia? Clinical Research/Applications
Author Affiliations & Notes
  • Earl L Smith
    College of Optometry, University of Houston, Houston, Texas, United States
  • Footnotes
    Commercial Relationships   Earl Smith, Nevarka (C), SightGlass Vision (C), Treehouse Eyes (C), Zeiss (P)
  • Footnotes
    Support  NIH Grant EY03611-36
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3291. doi:https://doi.org/
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      Earl L Smith; Can manipulation of the retinal ON- OFF-pathways prevent myopia? Clinical Research/Applications. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3291. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : The ON and OFF pathways are a fundamental organizational property of the retina and activity within these two distinct pathways can influence ocular growth and refractive development in qualitatively different ways. For example pharmacological blockade of the retinal ON pathway has been shown to promote hyperopia and to reduce lens-induced myopia. On the other hand, elimination of OFF responses reduces the hyperopia normally produced by imposed myopic defocus. Moreover the ocular effects of manipulations of ambient lighting and image contrast polarity that are designed to differentially stimulate the ON and OFF pathways are in general agreement the results obtained using pharmacological blockade. The overall pattern of results suggest that it may be possible to prevent or control myopia progression using treatment regimens that selectively manipulate either the retinal ON and OFF pathways.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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