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David Troilo; How does the eye detect visual signals controlling eye growth?. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3292. doi: https://doi.org/.
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Presentation Description :
Experimentally imposing either myopic or hyperopic defocus on the retina results in predictable changes in eye growth and shape that change refractive state and compensate for the defocus. There has been some debate about whether or not the retina actually detects the sign of the defocus signal or is simply responding to different degrees of blur. In either case, there is little know about the mechanisms underlying the retinal sensitivity to defocus signals and the control of eye growth. This presentation will summarize evidence that the sign of defocus is detected by the retina through distinct molecular pathways to initiate a growth response to focus the eye. The possible mechanisms underlying the signal detection and growth responses will be discussed.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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