July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Subclinical choroidal neovascularizations in fellow-eyes of exudative age-related macular degeneration patients show a decrease in retinal sensitivity over time
Author Affiliations & Notes
  • Thomas Johannes Heesterbeek
    Ophthalmology, Radboudumc, Nijmegen, Netherlands
  • Yara Lechanteur
    Ophthalmology, Radboudumc, Nijmegen, Netherlands
  • Anita de Breuk
    Ophthalmology, Radboudumc, Nijmegen, Netherlands
  • Anneke I Den Hollander
    Ophthalmology, Radboudumc, Nijmegen, Netherlands
    Human Genetics, Radboudumc, Netherlands
  • Jeroen Klevering
    Ophthalmology, Radboudumc, Nijmegen, Netherlands
  • Thomas Theelen
    Ophthalmology, Radboudumc, Nijmegen, Netherlands
  • Carel C B Hoyng
    Ophthalmology, Radboudumc, Nijmegen, Netherlands
  • Footnotes
    Commercial Relationships   Thomas Johannes Heesterbeek, None; Yara Lechanteur, None; Anita de Breuk, None; Anneke Den Hollander, None; Jeroen Klevering, None; Thomas Theelen, None; Carel Hoyng, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3484. doi:
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      Thomas Johannes Heesterbeek, Yara Lechanteur, Anita de Breuk, Anneke I Den Hollander, Jeroen Klevering, Thomas Theelen, Carel C B Hoyng; Subclinical choroidal neovascularizations in fellow-eyes of exudative age-related macular degeneration patients show a decrease in retinal sensitivity over time. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3484.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the morphological and functional characteristics of preclinical manifestation of choroidal neovascularization(CNV) in fellow-eyes of exudative age-related macular degeneration (AMD) patients by means of multimodal imaging and microperimetry.

Methods : A total of 32 fellow-eyes without signs of exudation were screened for the presence of subclinical CNV. All patients were prospectively followed for 6 months using color fundus imaging (CFI), spectral domain optical coherence tomography (SD-OCT), optical coherence tomography angiography (OCTA) and microperimetry. In fellow-eyes with a subclinical CNV, microperimetry values of the neovascular area were compared with measurements in the center, mid-periphery and periphery of the macula in fellow-eyes without subclinical CNV at baseline and over follow-up.

Results : We detected six fellow-eyes (19%) at baseline with a subclinical CNV using OCTA. None of the patients presented with metamorphopsia or vision decline and there were no conclusive signs of exudative AMD on CFI and SD-OCT. Mean retinal sensitivity of the neovascular area (21.7 dB) was lower when compared with the mean retinal sensitivity in the center (26.1 dB), mid-periphery (25.6 dB) and periphery (24.6 dB) of the macula in fellow-eyes without subclinical CNV (P<0.001). After 6 months, mean retinal sensitivity of the neovascular area was lower when compared with the baseline measurements (difference of -3.0 dB, P<0.001). In fellow-eyes without subclinical CNV, mean retinal sensitivity did not change between baseline and follow-up.

Conclusions : Subclinical CNV may be present in fellow-eyes of patients with unilateral exudative AMD and can be detected with OCTA. Despite patients have no subjective visual disturbances, microperimetry can show a subtle decrease in retinal sensitivity over time.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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