Abstract
Purpose :
To investigate the features of the retinal pigment epithelium (RPE) on optical coherence tomography (OCT) in eyes with early age-related macular degeneration with reticular pseudodrusen.
Methods :
We classified the eyes into three types: type 1 has no undulating RPE; type 2 has undulating RPE; type 3 has wedge-shaped RPE detachment. We compared the retinal vessel densities, retinal thickness (RT) and choroidal thickness (CT) of a 3-mm-diameter zone.
Results :
We classified 33, 27, and 20 as types 1, 2, and 3, respectively. The vascular densities of the superficial and deep capillary plexus showed differences; type 1 (23.93 ± 2.26% and 23.54 ± 1.78%), type 2 (22.29 ± 2.80% and 21.94 ± 2.42%) and type 3 (21.93 ± 2.70% and 20.63 ± 2.42%, P = 0.010 and P < 0.001). The mean RT and CT were also different, type 1 (298.26 ± 13.81µm and 180.08 ± 55.49 µm), type 2 (285.29 ± 21.88 µm and 148.45 ± 55.08 µm) and type 3 (274.86 ± 20.62 µm and 135.75 ± 39.77 µm) (P = 0.001 and P = 0.007).
Conclusions :
Altered features of RPE on OCT might indicate advancement in disease and be part of an overall degeneration process in these eyes.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.