July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Morphologic features of the retinal pigment epithelium and associated chorioretinal characteristics in eyes with early age-related macular degeneration and reticular pseudodrusen
Author Affiliations & Notes
  • Cheolmin Yun
    Ophthalmology, Korea University College of Medicine, Korea (the Republic of)
  • Sungmin Jang
    Ophthalmology, Korea University College of Medicine, Korea (the Republic of)
  • So Min Ahn
    Ophthalmology, Korea University College of Medicine, Korea (the Republic of)
  • Ki Tae Nam
    Ophthalmology, Korea University College of Medicine, Korea (the Republic of)
  • Boram Lee
    Ophthalmology, Korea University College of Medicine, Korea (the Republic of)
  • Seong-Woo Kim
    Ophthalmology, Korea University College of Medicine, Korea (the Republic of)
  • Jaeryung Oh
    Ophthalmology, Korea University College of Medicine, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Cheolmin Yun, None; Sungmin Jang, None; So Min Ahn, None; Ki Tae Nam, None; Boram Lee, None; Seong-Woo Kim, None; Jaeryung Oh, None
  • Footnotes
    Support  This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03033092).
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3486. doi:https://doi.org/
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    • Get Citation

      Cheolmin Yun, Sungmin Jang, So Min Ahn, Ki Tae Nam, Boram Lee, Seong-Woo Kim, Jaeryung Oh; Morphologic features of the retinal pigment epithelium and associated chorioretinal characteristics in eyes with early age-related macular degeneration and reticular pseudodrusen. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3486. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the features of the retinal pigment epithelium (RPE) on optical coherence tomography (OCT) in eyes with early age-related macular degeneration with reticular pseudodrusen.

Methods : We classified the eyes into three types: type 1 has no undulating RPE; type 2 has undulating RPE; type 3 has wedge-shaped RPE detachment. We compared the retinal vessel densities, retinal thickness (RT) and choroidal thickness (CT) of a 3-mm-diameter zone.

Results : We classified 33, 27, and 20 as types 1, 2, and 3, respectively. The vascular densities of the superficial and deep capillary plexus showed differences; type 1 (23.93 ± 2.26% and 23.54 ± 1.78%), type 2 (22.29 ± 2.80% and 21.94 ± 2.42%) and type 3 (21.93 ± 2.70% and 20.63 ± 2.42%, P = 0.010 and P < 0.001). The mean RT and CT were also different, type 1 (298.26 ± 13.81µm and 180.08 ± 55.49 µm), type 2 (285.29 ± 21.88 µm and 148.45 ± 55.08 µm) and type 3 (274.86 ± 20.62 µm and 135.75 ± 39.77 µm) (P = 0.001 and P = 0.007).

Conclusions : Altered features of RPE on OCT might indicate advancement in disease and be part of an overall degeneration process in these eyes.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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