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Jawad Arshad, Daniel Culver, Kimberly Baynes, Sumit Sharma, Sunil K Srivastava; Sensitivity and Predictive Value of Radiography and ACE Levels in the Diagnosis of Sarcoid Uveitis. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3507.
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To examine the sensitivity and positive predictive value (PPV) of chest x-ray (CXR), chest computerized tomography (CT) scans and angiotensin-converting enzyme (ACE) against the gold standard of bronchoscopy in suspected sarcoid uveitis.
Retrospective study of 167 suspected sarcoid uveitis patients at the Cleveland Clinic Cole Eye Institute.
In this group, 44% had elevated ACE levels, 43% had positive CXR and 86% had a positive Chest CT. 77 patients underwent bronchoscopy and biopsy, 53% were positive. The sensitivity measurements were 48%, 74% and 96% for ACE, CXR, Chest CT respectively. The PPV measured 63% for ACE, 57% for CXR and 59% for Chest CT. In those with uveitis involving the posterior segment the PPV was 67%, 50% and 67% and the NPV was 43%, 58% and 75% for ACE, CXR and Chest CT respectively.
Chest CT scans had high sensitivity for the diagnosis of sarcoid in those with suspicious uveitis. The PPV was similar for ACE, CXR and Chest CT scans in comparison to the gold standard.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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