July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Clinical findings of paraneoplastic retinopathy with retinal ON bipolar cell dysfunction in Japanese cohort.
Author Affiliations & Notes
  • Satoshi Okado
    Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Shinji Ueno
    Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Ayami Nakanishi
    Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Daiki Inooka
    Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Hiroko Terasaki
    Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Footnotes
    Commercial Relationships   Satoshi Okado, None; Shinji Ueno, None; Ayami Nakanishi, None; Daiki Inooka, None; Hiroko Terasaki, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3539. doi:
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      Satoshi Okado, Shinji Ueno, Ayami Nakanishi, Daiki Inooka, Hiroko Terasaki; Clinical findings of paraneoplastic retinopathy with retinal ON bipolar cell dysfunction in Japanese cohort.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3539.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report the clinical findings of eyes with paraneoplastic retinopathy (PR) with retinal ON bipolar cell dysfunction.

Methods : Ten PR patients with retinal ON bipolar cell dysfunction, including 6 melanoma-associated retinopathy, from 8 institutions in Japan were evaluated for the presence of an autoantibody against transient receptor potential cation channel subfamily M member 1 (TRPM1). The results of ophthalmic examinations and the presence of anti-TRPM1 antibody were analyzed.

Results : The patients had similar clinical findings in both eyes at the time of diagnosis; relatively preserved BCVA, absence of fundus and OCT abnormalities, specific abnormalities of the electroretinography (ERGs); negative-type ERGs with bright stimulus flashes. Clinical course showed one patient whose retinal ON bipolar cells remained dysfunctional for the entire testing period. On the other hand, the ERGs recovered in 4 cases within 4 years after onset. Two cases progressed to additional impairment of the photoreceptors with deterioration of ERGs. Three cases had died and the clinical course was unavailable. In these 10 patients, five patients were positive for the anti-TRPM1 antibody. The clinical course of these eyes also different, one case remained retinal ON bipolar cells dysfunctional, the ERGs recovered in 2 cases and one case progressed to deterioration of ERGs.

Conclusions : The clinical course of patients with retinal ON bipolar cell dysfunction can be different. Half of PR patients with retinal ON bipolar cell dysfunction possess autoantibodies against TRPM1.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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