July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Analysis on conjunctival vasculature using anterior segment optical coherence tomography angiography in patients with ocular surface squamous neoplasia
Author Affiliations & Notes
  • Kanako Nampei
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Yoshinori Oie
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Shoko Kiritoshi
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Misa Morota
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Shinnosuke Sato
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Reiko Kobayashi
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Satoshi Kawasaki
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Takeshi Nakao
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Takeshi Soma
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Shizuka Koh
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Kazuichi Maruyama
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Motokazu Tsujikawa
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Naoyuki Maeda
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Kohji Nishida
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Footnotes
    Commercial Relationships   Kanako Nampei, None; Yoshinori Oie, Carl Zeiss Meditec (F); Shoko Kiritoshi, None; Misa Morota, None; Shinnosuke Sato, None; Reiko Kobayashi, None; Satoshi Kawasaki, None; Takeshi Nakao, None; Takeshi Soma, None; Shizuka Koh, None; Kazuichi Maruyama, None; Motokazu Tsujikawa, None; Naoyuki Maeda, None; Kohji Nishida, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3558. doi:
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      Kanako Nampei, Yoshinori Oie, Shoko Kiritoshi, Misa Morota, Shinnosuke Sato, Reiko Kobayashi, Satoshi Kawasaki, Takeshi Nakao, Takeshi Soma, Shizuka Koh, Kazuichi Maruyama, Motokazu Tsujikawa, Naoyuki Maeda, Kohji Nishida; Analysis on conjunctival vasculature using anterior segment optical coherence tomography angiography in patients with ocular surface squamous neoplasia. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3558.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyze conjunctival vasculature using anterior segment optical coherence tomography angiography (AS-OCTA) in patients with ocular surface squamous neoplasia (OSSN)

Methods : We performed AS-OCTA scans for two eyes of two patients with OSSN to characterize pathologic change of conjunctival vasculature. Two 6×6 mm images were obtained.

Results : Case 1 is a 72-year-old female. Slit-lamp examination revealed elevated lesion and increased permeability of fluorescein located in nasal conjunctiva to limbus in her left eye. AS-OCTA demonstrated marked large blood vessel, and the blood vessel density was 60.1% in the regions of interest. Normal conjunctival vasculature patterns, centrifugal patterns in the surface layer and the segmental patterns in the deep layer, were not observed. We suspected OSSN and performed conjunctival biopsy. Histopathological diagnosis was conjunctival intraepithelial neoplasia (CIN). After tumor resection, postoperative course is good.
Case 2 is a 79-year-old man with a history of conjunctival tumor resection three times. Slit-lamp examination demonstrated elevated lesion and hyperpermeability of fluorescein in nasal conjunctiva to limbus in his left eye. AS-OCTA revealed increased vasculature, and the blood vessel density was 57.1%. Normal conjunctival vessel pattern was collapsed. OSSN was suspected, and tumor resection with amniotic membrane transplantation were performed. Histopathological investigation concluded that diagnosis was squamous cell carcinoma. Postoperative course is good.

Conclusions : AS-OCTA observation showed an increased blood vessel density and breakdown of normal conjunctival vasculature in patients with OSSN. It was suggested that these findings is useful for diagnosis of OSSN.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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