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Kanako Nampei, Yoshinori Oie, Shoko Kiritoshi, Misa Morota, Shinnosuke Sato, Reiko Kobayashi, Satoshi Kawasaki, Takeshi Nakao, Takeshi Soma, Shizuka Koh, Kazuichi Maruyama, Motokazu Tsujikawa, Naoyuki Maeda, Kohji Nishida; Analysis on conjunctival vasculature using anterior segment optical coherence tomography angiography in patients with ocular surface squamous neoplasia. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3558.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze conjunctival vasculature using anterior segment optical coherence tomography angiography (AS-OCTA) in patients with ocular surface squamous neoplasia (OSSN)
We performed AS-OCTA scans for two eyes of two patients with OSSN to characterize pathologic change of conjunctival vasculature. Two 6×6 mm images were obtained.
Case 1 is a 72-year-old female. Slit-lamp examination revealed elevated lesion and increased permeability of fluorescein located in nasal conjunctiva to limbus in her left eye. AS-OCTA demonstrated marked large blood vessel, and the blood vessel density was 60.1% in the regions of interest. Normal conjunctival vasculature patterns, centrifugal patterns in the surface layer and the segmental patterns in the deep layer, were not observed. We suspected OSSN and performed conjunctival biopsy. Histopathological diagnosis was conjunctival intraepithelial neoplasia (CIN). After tumor resection, postoperative course is good.Case 2 is a 79-year-old man with a history of conjunctival tumor resection three times. Slit-lamp examination demonstrated elevated lesion and hyperpermeability of fluorescein in nasal conjunctiva to limbus in his left eye. AS-OCTA revealed increased vasculature, and the blood vessel density was 57.1%. Normal conjunctival vessel pattern was collapsed. OSSN was suspected, and tumor resection with amniotic membrane transplantation were performed. Histopathological investigation concluded that diagnosis was squamous cell carcinoma. Postoperative course is good.
AS-OCTA observation showed an increased blood vessel density and breakdown of normal conjunctival vasculature in patients with OSSN. It was suggested that these findings is useful for diagnosis of OSSN.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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