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Masahiko Sugimoto, Atsushi Ichio, Hisashi Matsubara, Mineo Kondo; The effects of intravitreal aflibercept on non-perfused areas and flicker ERGs in eyes with diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3640.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effects of intravitreal aflibercept (IVA) on non-perfused areas (NPAs) and flicker ERGs recorded with RETeval system with diabetic macular edema (DME).
Twenty-five eyes of 25 patients with DME (average age: 64.0+/-8.8 years) were treated with 3 consecutive monthly IVA. Fluorescein angiography (FA) and flicker ERGs (recorded with RETeval system, LKC Technologies, Inc) were performed prior to the IVA (baseline) and at 1 week after the third injection. The ischemic index (ISI), as a measurement of the NPAs, were determined. The correlation between ISI and implicit times or amplitudes of flicker ERGs were also determined.
ISI decreased from 55.5+/-20.4% (baseline) to 28.8+/-16.8%(after treatment, p<0.01, paired t-test). Implicit times changed from 31.3+/-3.3ms (baseline) to 31.5±3.1ms (after treatment), amplitudes changed from 12.2+/-5.5microV (baseline) to 11.3+/-6.1 microV (after treatment) with no significant differences. No Significant correlation was found between the reduction ratio of ISI and Implicit times or amplitudes during the treatment.
ISI and flicker ERG changed with different manner after IVA for DME.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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