Abstract
Purpose :
To evaluate the effects of intravitreal aflibercept (IVA) on non-perfused areas (NPAs) and flicker ERGs recorded with RETeval system with diabetic macular edema (DME).
Methods :
Twenty-five eyes of 25 patients with DME (average age: 64.0+/-8.8 years) were treated with 3 consecutive monthly IVA. Fluorescein angiography (FA) and flicker ERGs (recorded with RETeval system, LKC Technologies, Inc) were performed prior to the IVA (baseline) and at 1 week after the third injection. The ischemic index (ISI), as a measurement of the NPAs, were determined. The correlation between ISI and implicit times or amplitudes of flicker ERGs were also determined.
Results :
ISI decreased from 55.5+/-20.4% (baseline) to 28.8+/-16.8%(after treatment, p<0.01, paired t-test). Implicit times changed from 31.3+/-3.3ms (baseline) to 31.5±3.1ms (after treatment), amplitudes changed from 12.2+/-5.5microV (baseline) to 11.3+/-6.1 microV (after treatment) with no significant differences. No Significant correlation was found between the reduction ratio of ISI and Implicit times or amplitudes during the treatment.
Conclusions :
ISI and flicker ERG changed with different manner after IVA for DME.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.