July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
The effects of intravitreal aflibercept on non-perfused areas and flicker ERGs in eyes with diabetic macular edema
Author Affiliations & Notes
  • Masahiko Sugimoto
    Ophthalmology, Mie University School of Medicine, Tsu, MIE, Japan
  • Atsushi Ichio
    Ophthalmology, Mie University School of Medicine, Tsu, MIE, Japan
  • Hisashi Matsubara
    Ophthalmology, Mie University School of Medicine, Tsu, MIE, Japan
  • Mineo Kondo
    Ophthalmology, Mie University School of Medicine, Tsu, MIE, Japan
  • Footnotes
    Commercial Relationships   Masahiko Sugimoto, Bayer Yakuhin. Ltd (F); Atsushi Ichio, None; Hisashi Matsubara, Bayer Yakuhin. Ltd (F); Mineo Kondo, Bayer Yakuhin. Ltd (F)
  • Footnotes
    Support  Bayer Yakuhin. Ltd
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3640. doi:
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    • Get Citation

      Masahiko Sugimoto, Atsushi Ichio, Hisashi Matsubara, Mineo Kondo; The effects of intravitreal aflibercept on non-perfused areas and flicker ERGs in eyes with diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3640.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the effects of intravitreal aflibercept (IVA) on non-perfused areas (NPAs) and flicker ERGs recorded with RETeval system with diabetic macular edema (DME).

Methods : Twenty-five eyes of 25 patients with DME (average age: 64.0+/-8.8 years) were treated with 3 consecutive monthly IVA. Fluorescein angiography (FA) and flicker ERGs (recorded with RETeval system, LKC Technologies, Inc) were performed prior to the IVA (baseline) and at 1 week after the third injection. The ischemic index (ISI), as a measurement of the NPAs, were determined. The correlation between ISI and implicit times or amplitudes of flicker ERGs were also determined.

Results : ISI decreased from 55.5+/-20.4% (baseline) to 28.8+/-16.8%(after treatment, p<0.01, paired t-test). Implicit times changed from 31.3+/-3.3ms (baseline) to 31.5±3.1ms (after treatment), amplitudes changed from 12.2+/-5.5microV (baseline) to 11.3+/-6.1 microV (after treatment) with no significant differences. No Significant correlation was found between the reduction ratio of ISI and Implicit times or amplitudes during the treatment.

Conclusions : ISI and flicker ERG changed with different manner after IVA for DME.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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