July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Eigenlenses: an eigenvectors-based model for full crystalline lens shape description
Author Affiliations & Notes
  • Eduardo Martinez-Enriquez
    Visual Optics and Biophotonics Lab, Institute of Optics, CSIC, Madrid, Spain
  • Alberto De Castro
    Visual Optics and Biophotonics Lab, Institute of Optics, CSIC, Madrid, Spain
  • Ashik Mohamed
    Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Siobhan Williams
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Jean-Marie Parel
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Susana Marcos
    Visual Optics and Biophotonics Lab, Institute of Optics, CSIC, Madrid, Spain
  • Footnotes
    Commercial Relationships   Eduardo Martinez-Enriquez, US20170316571A1 (P); Alberto De Castro, None; Ashik Mohamed, None; Marco Ruggeri, None; Siobhan Williams, None; Jean-Marie Parel, None; Fabrice Manns, None; Susana Marcos, PCT/ES2012/070185 (P), US20170316571A1 (P)
  • Footnotes
    Support  Spanish Government Grant FIS2014-56643-R; Spanish Government Grant FIS2017-84753-R; European Project Presbyopia ERC-2011-AdG Ref. 294099; National Eye Institute Grants 2R01EY021834, P30EY14801 (Center Grant); the Hyderabad Eye Research Foundation; Florida Lions Eye Bank and the Beauty of Sight Foundation; Drs KR Olsen and ME Hildebrandt; Drs R Urs and A Furtado; the Henri and Flore Lesieur Foundation (JMP); an unrestricted grant from Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3687. doi:
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      Eduardo Martinez-Enriquez, Alberto De Castro, Ashik Mohamed, Marco Ruggeri, Siobhan Williams, Jean-Marie Parel, Fabrice Manns, Susana Marcos; Eigenlenses: an eigenvectors-based model for full crystalline lens shape description. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3687.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Accurate quantification of the full shape of the crystalline lens is essential for understanding accommodation and age-related disorders such as cataract and presbyopia. We propose a new method for the representation of the full crystalline lens geometry.

Methods : Isolated human crystalline lenses (n=76; 0-71y/o) immersed in preservation media were imaged using two custom-developed 3-D Optical Coherence Tomography (OCT) systems (OCT1, India, n=49; OCT2, Spain, n=27) with the anterior and the posterior surfaces facing the beam. Full shape 3-D models were obtained after automatic segmentation of the images, fan and optical distortion correction, tilt removal and registration. A laser ray tracing system was used to measure the lens spherical aberration (SA) in OCT1. Principal component analysis was applied to the lens models, previously normalized by their equatorial diameters (DIA), obtaining a new set of orthogonal basis (eigenlenses) allowing any 3-D lens to be expressed as a linear combination of eigenlenses. Root mean square (RMS) error between the actual lens full shape and its representation with eigenlenses was compared with the RMS using radii (Rs) of the best sphere fitting and radii (Rq) and asphericity (Q) of the best conicoid fitting of anterior (AL) and posterior (PL) surfaces.

Results : Mean RMS of eigenlenses representation (0.062±0.009 mm) was significantly lower than those using sphere (0.085±0.013 mm; p<0.01) and conicoid (0.082±0.016 mm; p<0.01) fittings with the same number of parameters. 1st, 4th & 5th eigenlenses mainly represent symmetric variations of the shape, while 2nd & 3rd represent non-symmetric variations. Age was modeled from 1st & 4th eigenlenses coefficients and DIA (multiple linear regression, R2=0.79, p<0.01), while R2 was lower when modeling with RqAL, RqPL and DIA (R2=0.60, p<0.01). Spherical aberration (6 mm pupil) was modeled from 1st, 3rd, 4th, 5th & 7th eigenlenses coefficients and DIA (R2=0.62, p<0.01) resulting in a higher R2 than with RqAL, RqPL, QAL, QPL, lens thickness and DIA (R2=0.53, p<0.01).

Conclusions : The new eigenlenses provide a more compact and accurate representation of the full shape of the lens than the classical models using radii of curvature and conic constants. Eigenlenses represent the crystalline lens as a whole, facilitating intuitive conclusions on geometrical changes of the lens, e.g., as a function of age, accommodation or refractive error.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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