July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Comparison of the characteristics and intracapsular fixation of new intraocular lens material to commercially available intraocular lens material
Author Affiliations & Notes
  • Kyoko Miura
    IOL Development Dept., Development Div., Eye Care Div., NIDEK Co., Ltd., Gamagori, AICHI, Japan
  • Yoshihiro Nakahata
    IOL Development Dept., Development Div., Eye Care Div., NIDEK Co., Ltd., Gamagori, AICHI, Japan
  • Satoshi Yokota
    IOL Development Dept., Development Div., Eye Care Div., NIDEK Co., Ltd., Gamagori, AICHI, Japan
  • Takahiro Tada
    IOL Development Dept., Development Div., Eye Care Div., NIDEK Co., Ltd., Gamagori, AICHI, Japan
  • Shinji Nagasaka
    IOL Development Dept., Development Div., Eye Care Div., NIDEK Co., Ltd., Gamagori, AICHI, Japan
  • Tsutomu Sunada
    IOL Development Dept., Development Div., Eye Care Div., NIDEK Co., Ltd., Gamagori, AICHI, Japan
  • Footnotes
    Commercial Relationships   Kyoko Miura, NIDEK Co., Ltd. (E); Yoshihiro Nakahata, NIDEK Co., Ltd. (E); Satoshi Yokota, NIDEK Co., Ltd. (E); Takahiro Tada, NIDEK Co., Ltd. (E); Shinji Nagasaka, NIDEK Co., Ltd. (E); Tsutomu Sunada, NIDEK Co., Ltd. (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3699. doi:
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    • Get Citation

      Kyoko Miura, Yoshihiro Nakahata, Satoshi Yokota, Takahiro Tada, Shinji Nagasaka, Tsutomu Sunada; Comparison of the characteristics and intracapsular fixation of new intraocular lens material to commercially available intraocular lens material. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3699.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the characteristics of a newly developed, hydrophobic acrylic intraocular lens (IOL) material (NMY07), and compare it to a material from a commercially available IOL (N4-18SYR). A secondary objective was to evaluate the intracapsular stability of IOLs made of different materials in an in vitro setting.

Methods : For both IOLs the glass-transition temperature was measured using differential scanning calorimetry (DSC), and the breaking strength and elongation at breakage were measured using a tensile tester. Additionally, the materials were stored in water at 100°C for 115 days (corresponding to 20 accelerated years according to the Arrhenius equation), and their long-term stability was evaluated based on changes before and after storage as confirmed by appearance size, and with a Fourier transform infrared spectrophotometer. Furthermore, each material was processed into the same shape as the NS-60YG (NIDEK;1-piece monofocal IOL), and the compression load and contact angle were measured in accordance with ISO 11979. To evaluate positional stability against vibration, each IOL was installed in a folder with an inner diameter of 10 mm, and vertically vibrated for 30 seconds at 10 Hz and 4 G acceleration. P<0.05 was considered statistically significant.

Results : Compared to N4-18SYR, the glass transition temperature of NMY07 was higher by 4.4°C, the breaking strength was 1.5 times higher, and the elongation at break was 2.7 times longer. No changes were observed in the dimensions and weight of the IOL, or in the material structure after the accelerated aging test. The compression forces were 0.8±0.12 mN and 0.8±0.17 mN for the N4-18SYR and NMY07 respectively (P>0.05). The contact angles were 145°±4.2° and 143°±2.2° for the N4-18SYR and NMY07 respectively (P>0.05). No rotation or displacement of the IOL caused by vibration for both materials (P>0.05, all comparisons).

Conclusions : The newly developed NMY07 had an improved glass-transition temperature, breaking strength, and elongation at breakage comparison to the material in a commercially available IOL (N4-18SYR). All other results were equivalent between materials. These outcomes indicate that the new IOL material (NMY07) has greater strength and is equivalent to existing material in the other characteristics.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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