July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Next generation diffractive multifocal contact lenses for presbyopia correction using LIRIC
Author Affiliations & Notes
  • Sam C. Butler
    Clerio Vision, Inc., Rochester, New York, United States
  • Cory Leeson
    Clerio Vision, Inc., Rochester, New York, United States
  • Krystel R Huxlin
    Flaum Eye Institute, University of Rochester, New York, United States
  • Jonathan D Ellis
    College of Optical Sciences, University of Arizona, Arizona, United States
  • Wayne Knox
    Institute of Optics, University of Rochester, New York, United States
  • Ian G Cox
    IGC Consulting, New York, United States
  • Geunyoung Yoon
    Flaum Eye Institute, University of Rochester, New York, United States
  • Scott M. MacRae
    Flaum Eye Institute, University of Rochester, New York, United States
  • Len Zheleznyak
    Clerio Vision, Inc., Rochester, New York, United States
  • Footnotes
    Commercial Relationships   Sam Butler, Clerio Vision, Inc. (I), Clerio Vision, Inc. (E), Clerio Vision, Inc. (P); Cory Leeson, Clerio Vision, Inc. (I), Clerio Vision, Inc. (E), Clerio Vision, Inc. (P); Krystel Huxlin, Clerio Vision, Inc. (F), Clerio Vision, Inc. (I), Clerio Vision, Inc. (P); Jonathan Ellis, Clerio Vision, Inc. (F), Clerio Vision, Inc. (C), Clerio Vision, Inc. (P), Clerio Vision, Inc. (R), Clerio Vision, Inc. (S); Wayne Knox, Clerio Vision, Inc. (F), Clerio Vision, Inc. (I), Clerio Vision, Inc. (C), Clerio Vision, Inc. (P), Clerio Vision, Inc. (R); Ian Cox, Clerio Vision, Inc. (C); Geunyoung Yoon, None; Scott MacRae, Clerio Vision, Inc. (C); Len Zheleznyak, Clerio Vision, Inc. (I), Clerio Vision, Inc. (E), Clerio Vision, Inc. (P)
  • Footnotes
    Support  NSF STTR Phase I: NSF/IIP 1549700; NSF STTR Phase II: NSF/IIP 1738506; CEIS: C090130; Research to Prevent Blindness
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3723. doi:
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    • Get Citation

      Sam C. Butler, Cory Leeson, Krystel R Huxlin, Jonathan D Ellis, Wayne Knox, Ian G Cox, Geunyoung Yoon, Scott M. MacRae, Len Zheleznyak; Next generation diffractive multifocal contact lenses for presbyopia correction using LIRIC. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3723.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Laser induced refractive index change (LIRIC) has been previously demonstrated to create high optical quality, monofocal and multifocal wavefronts in hydrogel materials. The goal of the present study was to measure visual performance of diffractive multifocal, presbyopia-correcting contact lenses (CLs) produced with LIRIC.

Methods : A high repetition-rate, femtosecond laser system was used to modify the refractive index of plano hydrogel CLs (Acofilcon B, 49% water, 170 µm central thickness). The laser was focused within the CLs and scanned throughout a 5 mm diameter optical zone while simultaneously controlling scan speed and laser power. The LIRIC process produced a diffractive structure intended to produce a multifocal wavefront with a +2.5 D add power and approximately 70/30% energy split between distance and near vision, respectively. Lens dimensions were measured before and after laser treatment with optical coherence tomography (OCT) to ensure integrity of the CLs. Visual quality was assessed in terms of through-focus high-contrast tumbling-E visual acuity (VA) in two conditions: 1) with the LIRIC diffractive multifocal (DMF) and 2) with an untreated control (CON) contact lens. Both conditions were assessed monocularly, in white light, in 12 cyclopleged eyes of 6 subjects viewing through a 4 mm diameter artificial pupil.

Results : The diffractive multifocal wavefronts were imparted into the CLs at a depth of 100 µm. Imaging the CLs with OCT revealed negligible changes in center thickness (-0.3±0.8%) and base curvature (0.5±0.6%). Subjects performed well at distance, with best-corrected distance VA for the DMF and CON lenses averaging 0.02±0.08 and -0.05±0.05 logMAR, respectively. Both lenses performed similarly for intermediate object distances between 0.5 and 1.5 D. Importantly, the DMF lens yielded significant visual benefit over the CON lens for near object distances (2.1 and 2.4 lines of visual benefit at 2.5 and 3.0 D object distances, respectively).

Conclusions : Diffractive multifocality in soft contact lenses is an effective method of increasing the eye’s depth of focus for presbyopia correction. LIRIC removes previous barriers to employing diffractive technology in soft contact lenses by preserving surface integrity and imparting the diffractive wavefront internally to the lens.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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