July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Design and Evaluation of a Specular Microscope that incorporates the Scheimpflug Principle
Author Affiliations & Notes
  • Michihiro Takii
    NIDEK, Gamagori, AICHI, Japan
    NIDEK, Gamagori, AICHI, Japan
    NIDEK, Gamagori, AICHI, Japan
  • Masaaki Hanebuchi
    NIDEK, Gamagori, AICHI, Japan
  • Footnotes
    Commercial Relationships   Michihiro Takii, None; HIROKI YOKOSUKA, None; HIROKAZU NAKAMURA, None; Masaaki Hanebuchi, None
  • Footnotes
    Support  NONE
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3831. doi:
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      Michihiro Takii, HIROKI YOKOSUKA, HIROKAZU NAKAMURA, Masaaki Hanebuchi; Design and Evaluation of a Specular Microscope that incorporates the Scheimpflug Principle. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3831.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : A specular microscope is a commonly used non-contact device to image corneal endothelial cells. However the oblique imaging method to achieve specular reflection results in a deterioration (defocus) of the peripheral image capture area. We evaluate a prototype device that uses the Scheimpflug optical design for endothelial imaging that reduces image deterioration over the entire capture area.

Methods : (1) Design: Based on the Scheimpflug principle, the objective lens was tilted with respect to the light receiving optical axis. The image capture area was 0.25 x 0.55 mm that is similar to the conventional device (CEM-530 by NIDEK).
(2) Evaluation of the prototype: A resolution chart was placed at each position in the image capture area, and each resolution was evaluated. Human eye images were also captured to compare them with the CEM-530.

Results : (1) Design: The Scheimpflug optical system design can be implemented with a size that is consistent with current clinical devices (working distances of 40 mm or more). The Modulation Transfer Function (MTF) value at a spatial frequency of 160 cycles/mm is 0.2 or greater over the entire image capture area.
(2) Prototype evaluation: A spatial frequency of 250 cycles/mm on a resolution chart was resolved in the peripheral image capture area. Imaging of human eyes indicated reduced image deterioration (defocus) in the peripheral regions imaging area.

Conclusions : A specular microscope that incorporates the Scheimpflug optical system can be produced for use in the clinical environment. The prototype device has provided high-resolution images over the entire capture area.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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