July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Asteroid Hyalosis in United States Adults
Author Affiliations & Notes
  • Rebecca McNeill Sieburth
    Department of Ophthalmology, University of Virginia, Charlottesville, Virginia, United States
  • Mary Qiu
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Sreekanth Mallikarjun
    McIntire School of Commerce, University of Virginia, Charlottesville, Virginia, United States
  • Yevgeniy Shildkrot
    Department of Ophthalmology, University of Virginia, Charlottesville, Virginia, United States
  • Footnotes
    Commercial Relationships   Rebecca Sieburth, None; Mary Qiu, None; Sreekanth Mallikarjun, None; Yevgeniy Shildkrot, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3944. doi:
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      Rebecca McNeill Sieburth, Mary Qiu, Sreekanth Mallikarjun, Yevgeniy Shildkrot; Asteroid Hyalosis in United States Adults. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3944.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Asteroid hyalosis is an uncommon, typically asymptomatic condition. Previous population based studies have identified possible associations between asteroid hyalosis and various systemic conditions. The purpose of this study is to examine the prevalence of asteroid hyalosis and identify associated conditions in a population representative of United States adults.

Methods : Population-based, cross-sectional study of adults age 40 and older from the 2005-2008 National Health and Nutrition Examination Survey (NHANES). Main outcome measures were asteroid hyalosis on fundus photography in any eye. Statistical analysis was performed with R Version 3.5.1. Serial logistic regression was carried out to identify associations between specific factors and presence of asteroid hyalosis.

Results : A total of 5,578 subjects over the age of 40 underwent fundus photography. Average age at the time of screening was 59.4 years, with 2,792 (50.1%) women and 2,786 (49.9%) men. Asteroid hyalosis was identified in 56 eyes of 48 subjects, with an observed prevalence of 0.86%. Of these 48 subjects, 27 (56.3%) were male and 21 (43.7%) were female, with sex specific prevalence of 0.97% in men and 0.76% in women. In 4 subjects (16.7%), asteroid hyalosis was present bilaterally.
Asteroid hyalosis was associated with increasing age (p<0.0001, 95% confidence interval [CI], 0.06-0.12; odds ratio [OR], 1.09). There were no significant associations with ethnicity or sex. After adjusting for age, ethnicity, and sex, asteroid hyalosis was associated with history of myocardial infarction (p=0.022) and weight in kilograms (p=0.049). Borderline associations were observed with waist circumference (p=0.073), history of coronary artery disease (p=0.079), and history of high cholesterol (p=0.087), which approached but did not reach statistical significance.
There were no significant associations with other factors including medical history, clinical examination, and laboratory testing. Asteroid hyalosis was not associated with diabetic retinopathy, macular edema, age-related macular degeneration, arteriovenous nicking, or cup to disc ratio.

Conclusions : Asteroid hyalosis is an uncommon clinical entity associated with older age, and may be associated with risk factors for cardiovascular disease. Further research is needed to identify possible shared pathophysiologic mechanisms between development of asteroid hyalosis and cardiovascular disease.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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