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Ning Danny Cheung, Miao Li Chee, Yih Chung Tham, Tien Yin Wong, Ching-Yu Cheng; Retinal vascular caliber and risk of cardiovascular disease: a prospective study in Asians. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3969. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the relationship between retinal vascular caliber and risk of incident cardiovascular disease (CVD) in a multi-ethnic Asian population.
We conducted a 6-year population-based cohort study of 6,379 Asian ethnic participants (Chinese, Malays and Indians), aged 40 years or older, residing in the general communities of Singapore, with no history of CVD at baseline. All participants had standardized general and ophthalmic examinations. Retinal vascular calibers, summarized as central retinal arteriolar (CRAE) or venular (CRVE) equivalents, were measured using a semi-automated computer-assisted program according to a standardized protocol.
Over the 6 years of follow-up, there were 231 cases of incident cardiovascular disease. In multi-variable analysis adjusted for age, gender, ethnicity, blood pressure, smoking, diabetes, hypertension and serum cholesterol level, wider CRVE was significantly associated with incident CVD (risk ratio [RR] 1.29; 95% confidence interval [CI]: 1.00, 1.69] for highest quartile of CRVE compared to other quartiles of CRVE). This association was mainly due to the association between wider CRVE and incident myocardial infarction (RR 1.53; 95% CI: 1.07, 2.19). There was no significant association between CRVE and incident stroke. There was also no association between CRAE and CVD events.
In this Asian population, our data suggest that persons with wider retinal venules may have 53% increased risk of myocardial infarction, independently of the conventional cardiovascular risk factors.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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