July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Retinal pigment epithelium apertures in chronic central serous chorioretinopathy
Author Affiliations & Notes
  • Enrico Peiretti
    Eye Clinic, University of Cagliari, Italy
  • Jay Chhablani
    L.V Prasad Eye Institute, India
  • Deepika C. Parameswarappa
    L.V Prasad Eye Institute, India
  • Marco Pellegrini
    S. Orsola-Malpighi University Hospital, University of Bologna, Italy
  • Giuseppe Giannaccare
    S. Orsola-Malpighi University Hospital, University of Bologna, Italy
    Eye Clinic, University of Cagliari, Italy
  • Footnotes
    Commercial Relationships   Enrico Peiretti, None; Jay Chhablani, None; Deepika C. Parameswarappa, None; Marco Pellegrini, None; Giuseppe Giannaccare, None; CLAUDIO IOVINO, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3971. doi:
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    • Get Citation

      Enrico Peiretti, Jay Chhablani, Deepika C. Parameswarappa, Marco Pellegrini, Giuseppe Giannaccare, CLAUDIO IOVINO; Retinal pigment epithelium apertures in chronic central serous chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3971.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To report retinal pigment epithelium (RPE) aperture as a possible evolution of serous pigment epithelium detachment (PED) in patients with chronic central serous chorioretinopathy (CSC).

Methods : Fifteen patients (17 eyes) with a diagnosis of avascular PED in chronic CSC were enrolled. All study participants had documented records of clinical examination, best correct visual acuity, fundus autofluorescence (FAF), fluorescein and indocyanine green angiography, spectral-domain optical coherence tomography and optical coherence tomography angiography (OCT-A). Primary outcomes measures were RPE aperture imaging analysis along with their temporal course.

Results : All eyes showed the RPE aperture as an interruption of the RPE in correspondence of the PED with neither sign of rippling nor retraction.Mean age was 59.4 ± 8.1years and mean BCVA was 0.34 ± 0.24 logMAR. In all eyes FAF displayed a well-circumscribed roundish hypoautofluorescence. Multimodal imaging and OCT-A confirmed the absence of any vascular network beneath the aperture in all study eyes. The mean time of follow up was 19.3 ± 14.3 months, and RPE discontinuities showed an increasing in size over time from 0.81 ± 0.39 mm2to 0.95 ± 0.45 (P= 0.005).

Conclusions : RPE aperture is a new finding in the setting of chronic CSC and it should be distinguished by RPE tears for the different pathogenesis and evolution in time.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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