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Julie Sanderson; P2X7 receptor in relation to glaucoma: Friend or Foe?. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4200.
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© ARVO (1962-2015); The Authors (2016-present)
Presentation Description :
The P2X7 receptor is expressed in the retina, associated with multiple cell types including Müller cells, microglia and retinal ganglion cells (RGCs). Activation of the RGC P2X7R leads to ATP-mediated excitotoxic cell death and the P2X7R is implicated in RGC degeneration in glaucoma. Indirect mechanisms may also contribute P2X7R-mediated RGC death and neuroinflammation following P2X7R-mediated cytokine release may also have a role to play. For example, in the ex vivo human retina, P2X7R stimulation causes secretion of IL-1β. IL-1β is a pro-inflammatory cytokine that is associated with neurodegeneration; it is, however, also reported to be neuroprotective. IL-10 is an anti-inflammatory cytokine; this is also secreted by the ex vivo human retina in response to P2X7R activation. Whether the P2X7R is a “friend” or “foe” in relation to RGC degeneration in glaucoma will be discussed.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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