July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Life beyond death; beneficial signaling by the P2X7 receptor
Author Affiliations & Notes
  • Claire H Mitchell
    University of Pennsylvania, Merion Station, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Claire Mitchell, None
  • Footnotes
    Support  NIH NEI R01 EY-013434, EY-015537
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4201. doi:
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      Claire H Mitchell; Life beyond death; beneficial signaling by the P2X7 receptor. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4201.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description : The P2X7 receptor for ATP was originally referred to as the “Death Receptor” and it has recently been linked to pathology in several ocular diseases. The P2X7 receptor is a non-selective cation channel, and prolonged opening of the channel can lead to cellular damage linked to excessive influx of calcium. Under certain conditions, efflux of potassium through the receptor can activate assembly of the NLRP3 inflammasome and subsequent release of IL-1beta. However, the channel is distributed throughout the healthy adult eye with multiple beneficial effects. The P2X7 receptor is important for visual signaling and ocular development. This presentation will discuss the costs and benefits of targeting the P2X7 receptor directly and raise the possibilities of alternative targets.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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