July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Choriocapillaris Flow Deficits Around Geographic Atrophy Correlate with Enlargement Rates Based on Swept Source OCT Angiographic Imaging
Author Affiliations & Notes
  • Philip J. Rosenfeld
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Marie Thulliez
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Qinqin Zhang
    Department of Bioengineering, University of Washington, Seattle, Seattle, Washington, United States
  • Yingying Shi
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Hao Zhou
    Department of Bioengineering, University of Washington, Seattle, Seattle, Washington, United States
  • Zhongdi Chu
    Department of Bioengineering, University of Washington, Seattle, Seattle, Washington, United States
  • Luis De Sisternes
    Research and Development, Carl Zeiss Meditec, Dublin, California, United States
  • Mary K Durbin
    Research and Development, Carl Zeiss Meditec, Dublin, California, United States
  • William Feuer
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Cancan Lyu
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Giovanni Gregori
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Ruikang K Wang
    Department of Bioengineering, University of Washington, Seattle, Seattle, Washington, United States
  • Footnotes
    Commercial Relationships   Philip Rosenfeld, Carl Zeiss Meditec (F), Carl Zeiss Meditec (C); Marie Thulliez, None; Qinqin Zhang, None; Yingying Shi, None; Hao Zhou, None; Zhongdi Chu, None; Luis De Sisternes, Carl Zeiss Meditec (E); Mary Durbin, Carl Zeiss Meditec (E); William Feuer, None; Cancan Lyu, None; Giovanni Gregori, Carl Zeiss Meditec (F), Carl Zeiss Meditec (P); Ruikang Wang, Carl Zeiss Mediec (C), Carl Zeiss Meditec (P)
  • Footnotes
    Support  Carl Zeiss Meditec, Inc. (Dublin, CA), the National Eye Institute (R01EY024158, R01EY028753), the Salah Foundation, an unrestricted grant from the Research to Prevent Blindness, Inc., New York, NY, and the National Eye Institute Center Core Grant (P30EY014801) to the Department of Ophthalmology, University of Miami Miller School of Medicine.
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4219. doi:https://doi.org/
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      Philip J. Rosenfeld, Marie Thulliez, Qinqin Zhang, Yingying Shi, Hao Zhou, Zhongdi Chu, Luis De Sisternes, Mary K Durbin, William Feuer, Cancan Lyu, Giovanni Gregori, Ruikang K Wang; Choriocapillaris Flow Deficits Around Geographic Atrophy Correlate with Enlargement Rates Based on Swept Source OCT Angiographic Imaging. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4219. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine if the enlargement rates (ERs) of geographic atrophy (GA) correlated with the percentage and size of choriocapillaris (CC) flow deficits (FDs) surrounding GA, we imaged the FDs and the ERs of GA using swept source optical coherence tomography (SS-OCT).

Methods : Patients with GA secondary to non-exudative AMD were imaged using a 100-kHz SS-OCT instrument (PLEX Elite 9000, Carl Zeiss Meditec). A 6x6mm scan pattern was performed. GA area measurements were obtained from en face SS-OCT sub-RPE slab images. Visualization of the CC and quantification of FDs were performed using SS-OCT angiography (SS-OCTA). The percentage of CC FDs (FD%) and the average FD area measurements were calculated in regions surrounding the GA.

Results : In 22 eyes of 15 patients, the annual square root ERs for GA ranged from 0.07 to 0.75 mm/year. The highest FD values were found in the region closest to the margin of GA. The strongest correlations were found between the ERs and average CC FD area measurements away from the margin of GA and calculated from the total scan area minus the area of GA (p<0.001).

Conclusions : Contrary to expectations, the strongest correlations between the ER of GA and CC FDs were found when the entire scan area minus the area of GA was used rather than the region immediately around the GA.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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