July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Correlation of axial lengths with aqueous humor concentrations of cytokines in eyes with congenital cataract
Author Affiliations & Notes
  • pingjun chang
    Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
  • Fan Zhang
    Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
    Wenzhou medical university, China
  • Yune zhao
    Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
  • Footnotes
    Commercial Relationships   pingjun chang, None; Fan Zhang, None; Yune zhao, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4308. doi:
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      pingjun chang, Fan Zhang, Yune zhao; Correlation of axial lengths with aqueous humor concentrations of cytokines in eyes with congenital cataract. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4308.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the association between the components of the aqueous humor (AH) in patients with congenital cataracts and the axial lengths also its growth.

Methods : Aqueous humor samples were collected from 25 eyes of 17 patients with . congenital cataracts undergoing congenital cataract extraction and intraocular lens implantation. Collecting 0.1 ml AH of patients during the surgery. Multiplex enzyme-linked immunosorbent assays (ELISAs) and Luminex xMAP technology were used to assess 45 cytokines/chemokines, matrix metalloproteinases (MMPs), and acute-phase proteins in the identification cohort. Axial lengths were measured before the surgery and 3 months, 6 months and 1 year after the surgery.

Results : There was a negative correlation between aqueous humor level of VEGF and the preoperative axial lengths (r=-0.511,p<0.01). Similar trends were observed in the aqueous humor levels of GM-CSF and CCL11/Eotaxin, levels decreased with an increase in the axial length (r=-0.496,p=0.01; r=-0.419,p=0.037). And a negative correlation was found between the level of PDGF-BB and the change of the axial lengths in 1 year after surgery.( r=-0.462, p=0.02). There was no correlation between the changes of axial lengths and axial lengths(p>0.05).

Conclusions : Axial lengths were significantly negatively correlated with aqueous humor levels of VEGF, GM-CSF and CCL11/Eotaxin. And the level of PDGF-BB was negatively correlated with the change of the axial lengths in 1 year after surgery. The components of the AH may be of predictive value for axial prediction in patients with congenital cataracts and may, thus, be a useful prognostic modality.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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