Abstract
Purpose :
To investigate the association between the components of the aqueous humor (AH) in patients with congenital cataracts and the axial lengths also its growth.
Methods :
Aqueous humor samples were collected from 25 eyes of 17 patients with . congenital cataracts undergoing congenital cataract extraction and intraocular lens implantation. Collecting 0.1 ml AH of patients during the surgery. Multiplex enzyme-linked immunosorbent assays (ELISAs) and Luminex xMAP technology were used to assess 45 cytokines/chemokines, matrix metalloproteinases (MMPs), and acute-phase proteins in the identification cohort. Axial lengths were measured before the surgery and 3 months, 6 months and 1 year after the surgery.
Results :
There was a negative correlation between aqueous humor level of VEGF and the preoperative axial lengths (r=-0.511,p<0.01). Similar trends were observed in the aqueous humor levels of GM-CSF and CCL11/Eotaxin, levels decreased with an increase in the axial length (r=-0.496,p=0.01; r=-0.419,p=0.037). And a negative correlation was found between the level of PDGF-BB and the change of the axial lengths in 1 year after surgery.( r=-0.462, p=0.02). There was no correlation between the changes of axial lengths and axial lengths(p>0.05).
Conclusions :
Axial lengths were significantly negatively correlated with aqueous humor levels of VEGF, GM-CSF and CCL11/Eotaxin. And the level of PDGF-BB was negatively correlated with the change of the axial lengths in 1 year after surgery. The components of the AH may be of predictive value for axial prediction in patients with congenital cataracts and may, thus, be a useful prognostic modality.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.