July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Peripapillary border tissue of the choroid and peripapillary ccleral flange in human eyes
Author Affiliations & Notes
  • Rahul Arvo Jonas
    Department of Ophthalmology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Germany
  • Leonard Holbach
    Department of Ophthalmology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Germany
  • Footnotes
    Commercial Relationships   Rahul Jonas, Patent holder with university of Heidelberg (Title: Agents for use in the therapeutic or prophylactic treatment of myopia or hyperopia; Europäische Patentanmeldung 15 000 771.4). (P); Leonard Holbach, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4318. doi:https://doi.org/
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    • Get Citation

      Rahul Arvo Jonas, Leonard Holbach; Peripapillary border tissue of the choroid and peripapillary ccleral flange in human eyes. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4318. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess dimensions and associations of the peripapillary border tissue of the choroid (PBT-C) and peripapillary scleral flange (PBT-S) within the optic nerve head region

Methods : The histomorphometric investigation included histologic sections of enucleated eyes of Caucasian patients. Using a light microscope, we measured the PBT dimensions.

Results : The study included 85 eyes (85 patients) with a mean age of 62.0±14.1 years (range:37-87 years) and mean axial length of 26.7±3.5 mm (range:21.0-37.0 mm). Thicker PBT-C thickness (mean:68.1±36.0µm) was associated with shorter axial length (P<0.001; regression coefficient r:-0.52). Longer PBT-C length (mean:531±802µm) was correlated with longer axial length (P<0.001;r:0.66). PBT-C cross-sectional area (18869±13839µm2) was not significantly associated with axial length (P=0.37). The angle between PBT-C and Bruchs membrane (mean:80±53°) decreased with longer axial length (P<0.001;beta:0.70). In non-highly myopic eyes without overhanging Bruchs membrane, the angle was approximately 90°, in eyes with Bruchs membrane overhanging into the intrapapillary region, the angle ranged between 100° and 180°, and in eyes with parapapillary gamma zone, the angle was close to 0°. Thickness of PBT-S (mean:83.0±21.3µm) was correlated neither with axial length (P=0.28) or glaucoma (P=0.17). Optic nerve pia mater thickness (mean:109±44µm) increased with the glaucoma presence (P=0.007;beta:0.41) but not with axial length (P=0.45).

Conclusions : PBT-C and PBT-S as continuation of the optic nerve pia mater are distinct structures with the PBT-C re-modelling with longer axial length and the PBT-S being independent of axial elongation. PBT-C and PBT-S may be of importance for the optic nerve head biomechanics and separation of the choroidal space from the intrapapillary compartment.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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