July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Histomorphometry of the choriocapillaris in high myopia
Author Affiliations & Notes
  • Songhomitra Panda-Jonas
    Augenpraxis Dr. Panda-Jonas Prof. Jonas, Heidelberg, Heidelberg, Germany
  • Jost B Jonas
    Medical Faculty Mannheim, University Heidelberg, Germany, Germany
  • Footnotes
    Commercial Relationships   Songhomitra Panda-Jonas, Patent holder with Biocompatible UK Ltd. (Title: Treatment of eye diseases using encapsulated cells encoding and secreting neuroprotective factor and / or anti-angiogenic factor; Patent number: 20120263794), and (together with Rahul Jonas and Shefali Jonas) patent application with university of Heidelberg (Title: Agents for use in the therapeutic or prophylactic treatment of myopia or hyperopia; Europäische Patentanmeldung 15 000 771.4). (P); Jost Jonas, Patent holder with Biocompatible UK Ltd. (Title: Treatment of eye diseases using encapsulated cells encoding and secreting neuroprotective factor and / or anti-angiogenic factor; Patent number: 20120263794), and (together with Rahul Jonas and Shefali Jonas) patent application with university of Heidelberg (Title: Agents for use in the therapeutic or prophylactic treatment of myopia or hyperopia; Europäische Patentanmeldung 15 000 771.4). (P)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4350. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Songhomitra Panda-Jonas, Jost B Jonas; Histomorphometry of the choriocapillaris in high myopia. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4350.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Myopic axial elongation is associated with choroidal thinning in general. We examined whether the thickness of the choriocapillaris decreases in relationship to axial length.

Methods : Sagittal histological sections of human globes enucleated due to malignant choroidal melanomas or secondary angle-closure glaucoma were histomorphometrically examined.

Results : The study included 62 globes with a mean age of 62.0 ±18.8 years (range: 24-88 years). The choriocapillaris was significantly (P=0.002) thickest at the fovea (7.8±7.0µm (median: 5.0µm; range:0.00-30.0µm) followed by the midpoint between fovea and equator (5.4±4.1µm;median:4.8µm;range:0-15.0µm), where it was tendentially thicker (P=0.08) than at the equator (4.5±3.7µm;median:3.8µm;range:0-19.5µm) with no significant (P=0.30) difference from there to the ora serrata (4.9±4.0µm;median:4.8µm; range:0-19.5µm). At all measurement points, the choriocapillaris thickness was not significantly associated with axial length (fovea: P=0.82; midpoint fovea/equator: P=0.49; equator: P=0.47; ora serrata: P=0.08) or with the diagnosis of glaucoma (fovea: P=0.86; midpoint fovea/equator: P=0.29; equator: P=0.96; ora serrata: P=0.81). As a corollary, the sequence of the ocular regions in choriocapillaris thickness was independent of axial length (all P>0.05) and glaucoma (all P>0.05).

Conclusions : In human eyes, the thickness of the choriocapillaris in the subfoveal region or any other ocular region was not significantly related to axial length. The findings are helpful to explain the clinical finding of a full best-corrected visual acuity in myopic eyes without myopic macular Bruchs membrane defects.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×