July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Topical use of corticosteroids in the treatment of ocular myasthenia gravis
Author Affiliations & Notes
  • Minghua Shi
    Department of Pediatric Ophthalmology and Strabismus , Hanyang Aier Eye Hospital, Wuhan, Hubei, China
  • Footnotes
    Commercial Relationships   Minghua Shi, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4443. doi:
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      Minghua Shi; Topical use of corticosteroids in the treatment of ocular myasthenia gravis . Invest. Ophthalmol. Vis. Sci. 2019;60(9):4443.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To explore the treatment of ocular myasthenia gravis(OMG). with local injection of dexamethasone extraocular muscle (mainly Medial rectus muscle) and observe its therapeutic effect.

Methods : Patients with ocular myasthenia gravis who were newly diagnosed in our hospital from August 2016 to August 2018 were enrolled in this study. The acne muscles (mainly the medial rectus) were injected with dexamethasone injection. Once a week, 4-6 times according to the patient's response to the treatment. Observe the changes of patients' condition before and after treatment, including diplopia, ptosis, eye position, eye movement and so on. If the patient's condition recovers, it will be reviewed once a month and followed up for more than 3 months.

Results : A total of 12 patients received this treatment. There were 5 males and 7 females, aged from 8 to 12 years, with an average of 46±15 years old. All patients were completely relieved after local injection of dexamethasone into the paralysed extraocular muscles. The symptoms of diplopia and blepharoptosis disappeared and the eyeball movement recovered The average recovery time is 3.2 weeks. Except for local subconjunctival hemorrhage caused by injection, no other local or systemic complications were found, and no recurrence was observed during follow-up.

Conclusions : Local injection of dexamethasone on paralysed extraocular muscles for the treatment of ocular myasthenia gravis is effective and may be an alternative to systemic drug treatment..However, the current number of cases is small and the observation time is also short, so the exact efficacy still needs to be studied on a large scale.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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