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So Makino, Tatsuya Inoue, Han Peng Zhou, Takumi Hara, Hiroshi Murata, Ryo Asaoka, Ryo Obata; Comparison of standard automated perimetry and short wavelength automated perimetryto evaluate the structure-function relationship in retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4484.
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© ARVO (1962-2015); The Authors (2016-present)
Retinitis pigmentosa (RP) is a progressive retinal disease characterized by night blindness and visual field constriction. Previously, we reported that retinal sensitivity measured with microperimeter (MP-3, Nidek, Japan) better reflects the magnitude of structural damage in RP patients, compared with a standard automated perimeter (SAP). Short wavelength automated perimetry (SWAP) are known to detect visual field damage at an earlier stage than SAP in glaucoma. There are few reports describing the association between SWAP and retinal diseases.The purpose of the current study is to compare SWAP with SAP in RP patients and to investigate the correlation between retinal sensitivity measured with both perimetries and structural damage observed with optical coherence tomography (OCT).
Nineteen eyes of 15 patients with RP were enrolled in the present study.Retinal sensitivity (RS) was measured by white-on-white SAP (W/W) and blue-on-yellow SWAP (B/Y) in all examined eyes, using AP-7000 (KOWA, Japan). Visual field test was carried out using the standard Goldmann III stimulus size and a test grid was identical to the Humphrey Field Analyzer (HFA) 10-2 test pattern. Spectral domain OCT was also used to identify the ellipsoid zone (EZ) edge in each eye. The OCT images were superimposed onto HFA 10-2 test grid. The mean RS of W/W and B/Y within as well as the mean RS outside the EZ edge were calculated.
The mean (±SD) age of RP patients was 47.6 (±13.0) years. The mean retinal sensitivity inside the EZ edge was 30.8 (±3.5) and 24.7 (±2.5) dB, with W/W and B/Y perimetry, respectively. The mean retinal sensitivity outside the EZ edge was 17.5 (±4.2) and 9.2 (±4.3) dB, with W/W and B/Y perimetry, respectively. The difference between retinal sensitivity inside and outside of the EZ edge was significantly larger with B/Y perimetry than with W/W perimetry (p=0.001, paired t test).
Our findings suggest that retinal sensitivity measured with B/Y better reflects the magnitude of structural damage in RP patients, compared with W/W perimetry.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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