July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Comparison of two color vision tests in patients with Usher syndrome
Author Affiliations & Notes
  • Mathias Chapon
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, Paris, France
  • Isabelle S Audo
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, Paris, France
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
  • Auréline Costa
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, Paris, France
  • Marco Nassisi
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, Paris, France
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
  • Saddek Mohand Saïd
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, Paris, France
  • Jose-Alain Sahel
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, Paris, France
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
  • Footnotes
    Commercial Relationships   Mathias Chapon, None; Isabelle Audo, None; Auréline Costa, None; Marco Nassisi, None; Saddek Mohand Saïd, None; Jose-Alain Sahel, None
  • Footnotes
    Support  This work was performed in the frame of the RHU LIGHT4DEAF [ANR-15-RHU-0001] supported by French state funds managed by the ANR within the Investissements d’Avenir program
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4491. doi:https://doi.org/
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    • Get Citation

      Mathias Chapon, Isabelle S Audo, Auréline Costa, Marco Nassisi, Saddek Mohand Saïd, Jose-Alain Sahel; Comparison of two color vision tests in patients with Usher syndrome. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4491. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this work was to compare two color vision tests to assess chromatic discrimination in patients affected with Usher Syndrome, namely the color contrast sensitivity test measured by the Cambridge Colour Test and the Lanthony Desaturated D15.

Methods : Twenty-four patients (48 eyes), aged from 11 to 58 years (mean age 30.9), affected with Usher syndrome type I (29.2%), type II (66.6%) or type III (4.2%) were tested. Best corrected visual acuity using ETDRS charts (>logMar 0.5), kinetic visual field (>10° central), Lanthony Desaturated D15 panel and Cambridge Colour Test (CCT, Cambridge Research Systems, UK,low vision strategy with TriVector analysis) were performed for each eye on the same day. Each test was compared with a panel of fifteen healthy volunteers. Clinical parameters were subsequently analyzed, using IBM SPSS Statistics software v.21.0.

Results : Considering the CCT, 7/48 eyes were normal, 7/48 eyes had tritan defect, and 34/48 eyes were defined as multi-axis alterations.
Regarding the Lanthony desaturated D15, 17/48 eyes tested normal, 2/48 eyes had protan defect, 19/48 had tritan defect whereas 10/48 eyes profound abnormalities without any specific axis defect. Abnormalities of these tests were correlated with age and visual acuity. Both tests however defer statistically, with more color defects detected with CCT than the Lanthony D15.

Conclusions : The outcome allows us to conclude that there is a coherence between the reference examination, 15 HUE, and CCT used for the low visual acuity, in patients affected by Usher syndrome. However, the CCT proved to be more sensitive than 15 HUE in detecting dyschromatopsia.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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