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Jason Han Lee, Rohith Voora, Robert N Weinreb, Mohamad Moghadam, Christopher Bowd, James Proudfoot, Sasan Moghimi, Rafaella Penteado, Huiyuan Hou, Elham Ghahari, Patricia Isabel C Manalastas, Mark Christopher, Akram Belghith, Linda M Zangwill; Reduced Retinal Microvasculature with Increasing Axial Length and Older Age in Healthy Myopic and Non-Myopic Eyes. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4529. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the associations between axial length (AL), age, vessel density (VD) and retinal tissue thickness in healthy eyes.
105 eyes of 57 healthy myopic and non-myopic subjects (range of axial length: 21.6–28.4 mm) between the ages of 19 and 89 were imaged from the Diagnostic Innovations in Glaucoma Study (DIGS) using OptoVue Avanti macula (3 x 3 mm2) and optic nerve head (ONH, 4.5 x 4.5 mm2) scan protocols. Whole image superficial and deep layer macula VD and ONH whole image VD and capillary density (CD) (with large vessel removal) and peripapillary RNFL and GCC thicknesses were assessed from these scans. Multivariable linear mixed-effects models were used to assess the associations between age, AL, VD, CD, RNFL thickness, and GCC thickness after adjusting for image quality.
Mean (95% CI) axial length and age was 23.9 (23.6, 24.2) mm and 58.0 (54.3, 61.8) years, respectively. Multivariable models including age and image quality indicated that AL was significantly associated with a reduction in ONH whole image VD (−0.70% per mm, p=0.005) and CD (−0.55% per mm, p=0.027) and ONH peripapillary VD (−0.71% per mm, p=0.011) and CD (−0.65% per mm, p=0.020). AL was not significantly associated with superficial or deep layer macula VD (all p≥0.44) or any OCT-measured global GCC or RNFL thicknesses (all p≥0.267).Increasing age was also associated with a decrease in macula and ONH microvascular density. Specifically, in multivariable analysis increased age was associated with a reduction in: superficial macular whole image VD (−0.10% per year, p=0.002), superficial parafoveal VD (−0.08% per year, p=0.012), deep layer macular whole image VD (−0.06% per year, p=0.036), ONH whole image VD and CD (-0.06% and −0.05% per year, respectively both p <0.016) and peripapillary VD and CD (-0.07% and −0.05%, respectively both p<0.034). Age was also significantly associated with a reduction in global GCC (−0.035 μm per year, p<0.001) and RNFL thickness (−0.39 μm per year, p<0.001).
As the worldwide number of myopes increases and the population ages, information about age-related loss of microvasculature can inform the development of reference databases of vessel density measures to improve clinical evaluation of myopic and non-myopic eyes.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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