July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Evaluating diurnal changes in choroidal sublayer perfusion in patients diagnosed with epiretinal membrane using optical coherence tomography angiography
Author Affiliations & Notes
  • Felix Rommel
    Department of Ophthalmology, University of L�beck, Luebeck, Germany
  • Fynn Siegfried
    Department of Ophthalmology, University of L�beck, Luebeck, Germany
  • Max Brinkmann
    Department of Ophthalmology, University of L�beck, Luebeck, Germany
  • Salvatore Grisanti
    Department of Ophthalmology, University of L�beck, Luebeck, Germany
  • Mahdy Ranjbar
    Department of Ophthalmology, University of L�beck, Luebeck, Germany
  • Footnotes
    Commercial Relationships   Felix Rommel, None; Fynn Siegfried, None; Max Brinkmann, None; Salvatore Grisanti, None; Mahdy Ranjbar, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4534. doi:https://doi.org/
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      Felix Rommel, Fynn Siegfried, Max Brinkmann, Salvatore Grisanti, Mahdy Ranjbar; Evaluating diurnal changes in choroidal sublayer perfusion in patients diagnosed with epiretinal membrane using optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4534. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate diurnal changes in choroidal sublayer perfusion in eyes with idiopathic epiretinal membrane (ERM) and to identify influencing factors using optical coherence tomography angiography (OCTA).

Methods : A prospective study was conducted on volunteers with symptomatic ERM who each underwent repeated measurements of subfoveal choroidal thickness (SFCT) using enhanced-depth imaging (EDI) optical coherence tomography (OCT) and perfusion of choroidal vascular sublayers using OCTA at 7 a.m., 12 p.m., 4 p.m., and 8 p.m. Possible interactions between diurnal variations and other factors, such as mean arterial pressure (MAP), gender, and age, were evaluated.

Results : A total of 21 eyes of 21 participants (mean age 72.43 ± 7.06 years) were analyzed. A significant pattern of diurnal variation was observed for SFCT (p=0.008) as well as perfusion of Haller’s layer (HLP, p=0.001). SFCT and HLP both demonstrated a quadratic relation to time of the day, decreasing from morning to afternoon, before increasing again in the evening. No significant differences with regard to gender or age were detectable.

Conclusions : OCTA-based analysis of choroidal sublayer perfusion demonstrated significant diurnal variations in patients with symptomatic ERM. Therefore, it is important to account for time of day, when comparing longitudinal OCTA data.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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