July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Evaluation of ocular perfusion in patients with atrial fibrillation using optical coherence tomography angiography
Author Affiliations & Notes
  • Maged Alnawaiseh
    Dept. of Ophthalmology, University of Muenster Medical Center, Muenster, NRW, Germany
  • Philipp Sebastian Lange
    Department of Cardiovascular Medicine, University of Muenster Medical Center, Muenster, Germany
  • Eliane Esser
    Dept. of Ophthalmology, University of Muenster Medical Center, Muenster, NRW, Germany
  • Natasa Mihailovic
    Dept. of Ophthalmology, University of Muenster Medical Center, Muenster, NRW, Germany
  • Friederike Schubert
    Dept. of Ophthalmology, University of Muenster Medical Center, Muenster, NRW, Germany
  • Lars Eckardt
    Department of Cardiovascular Medicine, University of Muenster Medical Center, Muenster, Germany
  • Nicole Eter
    Dept. of Ophthalmology, University of Muenster Medical Center, Muenster, NRW, Germany
  • Footnotes
    Commercial Relationships   Maged Alnawaiseh, None; Philipp Sebastian Lange, None; Eliane Esser, None; Natasa Mihailovic, None; Friederike Schubert, None; Lars Eckardt, None; Nicole Eter, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4570. doi:
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      Maged Alnawaiseh, Philipp Sebastian Lange, Eliane Esser, Natasa Mihailovic, Friederike Schubert, Lars Eckardt, Nicole Eter; Evaluation of ocular perfusion in patients with atrial fibrillation using optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4570.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate retinal and optic nerve head (ONH) perfusion in patients with atrial fibrillation (AF) compared with healthy controls.

Methods : 44 eyes of 44 patients with AF (study group) and 45 eyes of 45 healthy subjects (control group) were prospectively included in this study. OCT-A was performed using RTVue XR Avanti with AngioVue (Optovue, Inc, Fremont, California, USA). The area of the foveal avascular zone (FAZ) and flow density data in the superficial and deep retinal OCT-angiogram of the macula and in the radial peripapillary capillary network (RPC) were extracted and analysed.

Results : There was no significant difference between the two groups in the area of the FAZ (study group: 0.26±0.10 mm2; control group: 0.29±0.10 mm2; p=0.20). The flow density (whole en face) in the superficial retinal OCT angiogram and in the OCT angiogram of the optic nerve head (RPC) were significantly lower in the AF group when compared with the control group (superficial: study group:50.80±3.05%; control group:52.29±3.14 %;p=0.012; RPC study group:52.65±4.00 %;control group:55.84±3.48 %;p<0.001).

Conclusions : Patients with AF showed a reduced flow density in the RPC layer and in the superficial retinal OCT angiogram when compared with healthy controls. Tus, AF should therefore be considered when evaluating flow density data in ocular diseases.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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