July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Predicting the progression of myopia in children
Author Affiliations & Notes
  • Divya Jagadeesh
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
  • Rebecca Y S Weng
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
  • Arthur Ho
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
  • Thomas John Naduvilath
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
  • Cathleen Fedtke
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
  • Monica Jong
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
  • Padmaja Sankaridurg
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
  • Footnotes
    Commercial Relationships   Divya Jagadeesh, None; Rebecca Weng, None; Arthur Ho, None; Thomas Naduvilath, None; Cathleen Fedtke, None; Monica Jong, None; Padmaja Sankaridurg, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4813. doi:
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    • Get Citation

      Divya Jagadeesh, Rebecca Y S Weng, Arthur Ho, Thomas John Naduvilath, Cathleen Fedtke, Monica Jong, Padmaja Sankaridurg; Predicting the progression of myopia in children. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4813.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Predicting the progression of myopia in children based on clinical features could allow identification of those requiring intervention and an earlier initiation of myopia management and hence a reduction to the risk of developing high myopia. We aimed to assess if optic disc and posterior segment features have the potential to predict a myopic shift in refractive error in children with myopia.

Methods : The study was approved by the AIER Institutional Ethics committee and parents/carers provided consent. Baseline fundus images of 56 (eyes) of 28 Chinese children with myopia who attended baseline and 12 months visit were analyzed. Fundus images were obtained using KOWA VX-10 alpha retinal camera. The fundus images were analysed using custom-coded Matlab software. Features assessed were optic disc tilt, rotation and asphericity, fovea-to-disc distance, superior and inferior ophthalmic retinal artery and vein angles at the disc, the presence of tessellations (quadrant wise),extend of temporal crescent at the optic disc.. The association of these features to the progression of spherical equivalent (SE) and axial length (AL) at 12 months was determined using the general linear model.

Results : Annual change in axial length was associated with disc tilt (p=0.017) and temporal crescent (p=0.002, model r2=0.18). Greater extent of temporal crescent, graded as 0 (absent), 1(< 900), 2(900-1800), 3(1800) and 4(>1800) correlated with lower AL progression. Similarly, there was an inverse relation with disc tilt, i.e. lower AL progression correlated with greater disc tilt, measured as the angle formed by global vertical and long axis of the optic disc. After adjusting for age, optic disc features remained significant (disc tilt p=0.043; temporal crescent p=0.018). Annual progression of SE followed a similar model with disc tilt (p=0.005) and temporal crescent (p=0.026, model r2=0.15).

Conclusions : In this small sample of myopic children, there was an association between the presence of temporal crescent at the disc and disc tilt with the progression of axial length and spherical equivalent. The results have to be confirmed using a larger sample.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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