July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Surgical feasibility of newly developed suprachoroidal–transretinal stimulation (STS) prosthesis in healthy dogs
Author Affiliations & Notes
  • Takeshi Morimoto
    Applied Visual Science, Osaka Univ Graduate Sch of Med, Suita, OSAKA, Japan
  • Tomomitsu Miyoshi
    Integrative physiology, Osaka University Graduate School of Medicine, Japan
  • Toru Saito
    Nidek Co., Japan
  • Kunihiko Ito
    Nidek Co., Japan
  • Motoki Ozawa
    Nidek Co., Japan
  • Kohji Nishida
    Ophthatmology, Osaka University Graduate School of Medicine, Japan
  • Takashi Fujikado
    Applied Visual Science, Osaka Univ Graduate Sch of Med, Suita, OSAKA, Japan
  • Footnotes
    Commercial Relationships   Takeshi Morimoto, Nidek (F); Tomomitsu Miyoshi, None; Toru Saito, Nidek (E); Kunihiko Ito, Nidek (E); Motoki Ozawa, Nidek (E); Kohji Nishida, None; Takashi Fujikado, Nidek (F), Nidek (P)
  • Footnotes
    Support  KAKENHI including Grant-in-Aid for Scientific Research (C) (Grant no. 26462684,), Scientific Research (B) (Grant no. 25293354),
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4984. doi:
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    • Get Citation

      Takeshi Morimoto, Tomomitsu Miyoshi, Toru Saito, Kunihiko Ito, Motoki Ozawa, Kohji Nishida, Takashi Fujikado; Surgical feasibility of newly developed suprachoroidal–transretinal stimulation (STS) prosthesis in healthy dogs. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4984.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the surgical feasibility of implanting a newly developed suprachoroidal–transretinal stimulation (STS) prosthesis in healthy dogs.

Methods : Four healthy dogs were used in this study. The STS prosthesis consisted of 49 electrodes. The array was implanted into a scleral pocket of each of four healthy beagle dogs under systemic anesthesia. Color fundus photography and fluorescein angiography (FA) were performed pre and postoperatively until 3-6 months. The animals were euthanatized after the experimental period and the retinas were evaluated histologically.

Results : All the prostheses were successfully implanted without complications, and no serious complications occurred during the experimental period. The fixation of the implant was stable throughout the experimental period. Fundus photographs and FAs revealed no serious damage in the retina and choroid around the array.
Histologic evaluations showed good preservation of the retina over the electrode array.

Conclusions : Implantation of a newly developed array STS retinal prosthesis into a scleral pocket of dogs is surgically feasible and can be performed without significant damage to the retina or the dog. The implanted STS prosthesis was biocompatible and remained stable for the experimental period. Further investigation is needed to rule out any influence of chronic electrical stimulation provided by this STS system on its biocompatibility and stability for a longer term follow-up.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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