Purchase this article with an account.
Santiago Soberón, Vanessa Tirado, Guillermo Salcedo- Villanueva, Luis A. Hernández, Elsa C. Hernández, Jazmin Baca Moreno, Luis Daniel Garcia Arzate, Enrique Garcia, Yurico Lopez, Ana Gonzalez-H.Leon, Ana Suárez Licona, Roberto Gonzalez-Salinas, Virgilio Morales-Canton, Hugo Quiroz-Mercado; Stargardt disease: Rapid quantification of color vision using the Rabin Cone Contrast Test. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5017.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
We intend to quantify acquired color vision deficiency in Stargardt disease patients by using the Rabin cone contrast test (RCCT).
Transversal, observational and descriptive study of 6 patients with Stargardt disease (12 eyes) and 6 healthy subjects (12 eyes) were evaluated using the Rabin cone contrast test [RCCT] (Innova Systems, Burr Ridge, IL.) Diagnosis of Stargardt disease was based on ophthalmic history, complete ophthalmic evaluation and complemented with genetic testing. A minimum best corrected visual acuity of 20/300 and 20/20 respectively were part of the inclusion criteria for evaluation. We compare their acuity test and their color perseption with LogMAR values and values from L, M and S CCT results respectively. Mann-Whitney U test was used to extablished a p value to settle the significance between case and control values.
Six patients with Stargardt disease with a mean age of 20.33±6.18 (range 12-26) years old and 6 healthy subjects with a mean age of 21.83±1.16 (range 21-24) years old were evaluated. RCCT detected that all Stargardt disease patients eyes conserved blue cones with a mean S CCTs of 62.9 (15-90), three eyes conserved green cones with a mean M CCTs of 25 (20-30) and four eyes conserved red cones with a mean L CCTs of 21.25 (10-35). The healthy subjects eyes RCCTs reported a mean S CCTs of 100, mean M CCTs of 99.5 (95-100) and a L CCTs of 95.4 (90-100). A significant p value was shown acording to Mann-Whitney test for visual acuity and RCCT results showing significant diference between both groups. Mann- Whitney test which showed visual acuity difference between cases and controls had a p value of 0.023 and RCCT difference with a p value of .0.40. Both comparisons had a significant p value.
Acquired color deficiency measured by RCCT and their visual acuity in Stargardt disease patients were significantly different from those measured on healthy subjects. The RCCT provides a rapid test (6 minutes) and findings from this study may potentially contribute to the rapid diagnosis of this disease, in comparison to other tests found in literature. Further research is needed to determine if the use of RCCT can be used as a follow up test of the progression of these patients.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
This PDF is available to Subscribers Only