Abstract
Purpose :
Idiopathic full-thickness macular hole (FTMH) is treated by vitrectomy with internal limitingmembrane (ILM) peeling with long-lasting inert gas tamponade routinely. We proposed this retrospective, case-matched study to investigate whether air tamponade is equivalent to gas tamponade.
Methods :
This study included 82 patients with idiopathic FTMH experienced vitrecto my/ILM peeling and air tamponade. We matched another 82 patients who were treated with vitrectomy/ILM peeling and C3F8 tamponade by age, gender, BCVA, size of macular hole, and range of ILM peeling. Preoperative and postoperative best corrected visual acuity(BCVA), intraocular pressure, spectral-domain optical coherence tomography (SD-OCT) were recorded for statistical analysis.
Results :
All patients were followed up 10.4 months(6-12 months). For air tamponade group, the postoperative BCVA at1 week, 1, 3, 6 months was 0.8±0.12，0.53±0.11, 0.32±0.02, 0.30±0.08 in LogMAR, 71 patients achieved macular hole closure (86.69%)by one operation, and additional 4 patients had successful macular hole closure by 1.6(1-3) times air-fluid exchange in office. In gas tamponade group, the postoperative BCVA at 1week, 1, 3, 6 months was 2.0±0.19，0.51±0.17, 0.33±0.16, 0.30±0.17 , 75 patients achievedmacular hole closure (91.46%) by one operation. There was no significant difference between the two groups either on postoperative BCVA after 1 month(p=0.453) or macular closure rate(p=0.629). The postoperative BCVA of air group was better than gas group at 1 week follow-up.
Conclusions :
<p style="margin: 0px;">Vitrectomy with ILM peeling is an effective treatment for idiopathic FTMH. Air tamponade can achieve faster vision recovery and similar final outcome both on visual acuity and macular hole closure rate compared with gas tamponade.
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This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.