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Han Peng Zhou, Tatsuya Inoue, Ryo Asaoka, Takumi Hara, So Makino, Hiroshi Murata, Ryo Obata; Short wavelength automated perimetry and standard achromatic perimetry in central serous chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5038.
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© ARVO (1962-2015); The Authors (2016-present)
Short wavelength automated perimetry (SWAP) is known for detecting reduction of retinal sensitivity in advance of standard achromatic perimetry in glaucoma patients. However, its application in other retinal diseases is still limited. In the current study, we investigated the difference in retinal sensitivity between standard white-on-white automated perimetry and blue-on-yellow SWAP in central serous chorioretinopathy (CSC) patients with macular serous retinal detachment (SRD).
Differences in retinal sensitivity (RS) between standard white-on-white automated perimetry (W/W) and blue-on-yellow SWAP (B/Y) was investigated in 24 eyes of 24 CSC patients with macular SRD. RS thresholds were measured within 10 degrees of the fovea. The mean overall RS of W/W (RSw) and B/Y (RSb) as well as the mean RS within (RSwin, RSbin) and outside (RSwout, RSbout) of the SRD region were calculated. Central retinal thickness (CRT), central choroidal thickness (CCT), SRD area (SRDa), and SRD height at the fovea (SRDh) were measured using spectral domain OCT. The correlation between RS (RSw, RSb) and OCT parameters (CRT, CCT, SRDa, SRDh) was assessed.
The mean age of the participants was 55.6 ± 11.6 years and the mean baseline logMAR BCVA was 0.056 ± 0.157. Among the 24 patients who completed the study, RSb was significantly lower than RSw (p < 0.001). Furthermore, the difference between the RS inside and outside of the SRD area (RSout – RSin) was significantly greater in B/Y compared to W/W (p < 0.001). Significant negative correlations were observed between logMAR BCVA and RSw (p < 0.001) and RSb (p < 0.001). SRDa was significantly related to both RSw and RSb (p < 0.001, respectively). In a series of multivariate analyses, logMAR BCVA was significantly related to CCT and SRDa (p<0.001, respectively). RSw was significantly related to age, SRDa, and SRDh (p<0.01, respectively). RSb was significantly related to age and SRDa (p < 0.001, respectively).
Our study demonstrated that blue-on-yellow SWAP is able to detect the difference in retinal sensitivity between inside and outside of the SRD region in advance of that by conventional achromatic perimetry in CSC patients. These results may suggest the usefulness of SWAP for early detection of the changes in retinal function in CSC.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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