July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Histopathology findings in the trabecular meshwork of eyes with glaucoma drainage devices
Author Affiliations & Notes
  • Jacqueline Coblentz
    Ocular Pathology, McGill University , Westmount, Quebec, Canada
  • Nabil Saheb
    Ocular Pathology, McGill University , Westmount, Quebec, Canada
  • Hady Saheb
    McGill University, Quebec, Canada
  • Paulina Garcia de Alba Graue
    Ocular Pathology, McGill University , Westmount, Quebec, Canada
  • Christina Mastromonaco
    Ocular Pathology, McGill University , Westmount, Quebec, Canada
  • Miguel N Burnier
    Ocular Pathology, McGill University , Westmount, Quebec, Canada
  • Footnotes
    Commercial Relationships   Jacqueline Coblentz, None; Nabil Saheb, None; Hady Saheb, None; Paulina Garcia de Alba Graue, None; Christina Mastromonaco, None; Miguel Burnier, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5163. doi:
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      Jacqueline Coblentz, Nabil Saheb, Hady Saheb, Paulina Garcia de Alba Graue, Christina Mastromonaco, Miguel N Burnier; Histopathology findings in the trabecular meshwork of eyes with glaucoma drainage devices. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5163.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : There is no data investigating how the implantation of GDD affects the trabecular meshwork components. In order to elucidate that question, we performed a histopathological analysis in post-mortem eyes with GDD. The aim of this study is to investigate whether alterations in the trabecular meshwork occur in eyes with GDD.

Methods : Four enucleated eyes with GDD (study group) and five normal eyes (control group) were obtained from the MUHC-McGill University Ocular Pathology & Translational Research Laboratory. The formalin fixed, paraffin embedded specimens were stained with Masson’s Trichrome. Histopathological features such as architecture of the Schlemm’s canal and fibrosis of the extracellular matrix were analyzed. Schlemm’s canal was classified as normal, dilated or collapsed and fibrosis was graded as 0=none, 1=moderate and 2=intense.

Results : Mean age in the study group was 66 years (SD=8) and 82 years (SD=12) in the control group. In the control group, all cases showed normal Schlemm’s canal and had no fibrosis. However, in the group with GDD, 1 case (25%) had collapse of the Schlemm’s canal and 3 (75%) had the canal dilated. Regarding fibrosis, 3 cases (75%) were grade 1 and 1 case was grade 2 (25%).

Conclusions : To the best of our knowledge, this is the first study to analyze histopathological features of trabecular meshwork in eyes with glaucoma drainage devices. There were changes to the trabecular meshwork in all cases with GDD, characterized as fibrosis and changes to the Schlemm’s canal structure. However, due to the few number of cases, further studies are needed in order to better understand the impact GDD causes in the trabecular meshwork.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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