July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Early Detection and Spatial Co-incidence of Localized Retinal Neuronal and Vascular Dysfunction in Diabetic Retinopathy
Author Affiliations & Notes
  • Yuen Ying Jacqueline Chan
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Ann-Marie Mora
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Jason H Hill
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Celina Villanueva
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Nasser Issa
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Luke Mein
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Joshua Michael Iltis
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • David Wilde
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Rene Renteria
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Divya Narayanan
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Randolph D Glickman
    UT Health San Antonio -Department of Ophthalmology, San Antonio, Texas, United States
  • Footnotes
    Commercial Relationships   Yuen Ying Chan, None; Ann-Marie Mora, None; Jason Hill, None; Celina Villanueva, None; Nasser Issa, None; Luke Mein, None; Joshua Iltis, None; David Wilde, None; Rene Renteria, None; Divya Narayanan, None; Randolph Glickman, None
  • Footnotes
    Support  Mike Hogg Fund
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5323. doi:https://doi.org/
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      Yuen Ying Jacqueline Chan, Ann-Marie Mora, Jason H Hill, Celina Villanueva, Nasser Issa, Luke Mein, Joshua Michael Iltis, David Wilde, Rene Renteria, Divya Narayanan, Randolph D Glickman; Early Detection and Spatial Co-incidence of Localized Retinal Neuronal and Vascular Dysfunction in Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5323. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Clinical experience suggests that early detection of diabetic retinopathy is key to treatment and management to maintain visual function and prevent complications. Current clinical practice is to evaluate individual tests such as Optical Coherence Tomography (OCT) and Electrodiagnostic testing (MfERG). We hypothesize that earlier detection of retinopathy may be achieved by correlating these tests, which was explored in this study.

Methods : In this ongoing study, 28 Hispanics, 14 Whites, and 6 Blacks (26 males and 22 females aged 56.5±10.9 years, ranging from 27 to 70 years) completed ERG, fundus, OCT, and diabetic eye exams. Patients were classified as either healthy control or as having diabetes with or without retinopathy. We excluded patients who had refractive surgeries, > 6D of refractive error, and other eye diseases. Three optometrists independently rated fundus photos utilizing ETDRS, using a scale from 0 (no abnormalities) to 3 (severe abnormalities) for OCT images. Descriptive statistics were collected on demographic data. MfERG averages were generated across rings 1 thru 5 (from 61 Diagnosys hexagons) for N1 and P1 amplitudes and latencies across OD and OS. We ran Wilks Shapiro tests of normality and Pearson’s & Spearman’s bivariate correlations to assess the statistical correlation of mfERG with images of the eye (fundus) and retina (OCT).

Results : Pearson’s test of fundus ratings with mfERG data revealed positive correlations pertaining to N1 amplitudes amongst rings 2 (r=0.30), 3 (r=0.29) & 5 (r=0.34) at P≤0.05 level across OS. Significant negative correlations were revealed among P1 amplitudes amongst rings 2 (r= -0.30), 3 (r= -0.30), 4 (r=-0.31) & 5 (r=-0.31) across OS. Analysis of OCT Ratings with mfERG data revealed correlations pertaining to OD ring 3 N1 amplitude (r=0.25), and ring 3 P1 latency (r=0.37) and OS ring 3 N1 latency (r=0.34). Spearman’s bivariate test yielded strong positive correlations of OCT and fundus ratings across OD (r=0.36, p=0.016) and OS (r=0.45, p=0.002).

Conclusions : Our results support a correlation between diagnostic data yielded from OCT, fundus photography, and mfERG data, suggesting that a concerted correlation of these tests may lead to earlier and more sensitive diagnosis of diabetic retinopathy. Other findings approached but did not achieve significance, likely due to small sample sizes.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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