July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Correlation between retinal vessel density and retinal layer thickness in eyes with proliferative diabetic retinopathy
Author Affiliations & Notes
  • Aditya Verma
    Doheny Eye Institute, California, United States
    David Geffen School of Medicine at UCLA, California, United States
  • Muneeswar Gupta Nittala
    Doheny Eye Institute, California, United States
  • Swetha Bindu Velaga
    Doheny Eye Institute, California, United States
  • Zhihong Hu
    Doheny Eye Institute, California, United States
  • Brenda Zhou
    Retina Consultants of Houston, Texas, United States
  • Shaun Lampen
    Retina Consultants of Houston, Texas, United States
  • Michael S Ip
    David Geffen School of Medicine at UCLA, California, United States
    DIRRL, Doheny Eye Institute, Los Angeles, California, United States
  • Charles Clifton Wykoff
    Retina Consultants of Houston, Texas, United States
  • Srinivas R Sadda
    Doheny Eye Institute, California, United States
    David Geffen School of Medicine at UCLA, California, United States
  • Footnotes
    Commercial Relationships   Aditya Verma, None; Muneeswar Gupta Nittala, None; Swetha Bindu Velaga, None; Zhihong Hu, None; Brenda Zhou, None; Shaun Lampen, None; Michael Ip, Allergan (C), Astellas Institute for Regenerative Medicine (C), Boehringer Ingelheim (C), Genentech (C), Omeros (C), Quark (C), Thrombogenics (C); Charles Wykoff, Adverum Biotechnologies, Inc (F), Aerpio Therapeutics (F), Alcon Laboratories (F), Alcon Laboratories, Inc (C), Alimera Sciences, Inc (C), Allergan, Inc (C), Allergan, Inc (F), Apellis Pharmaceutical (C), Apellis Pharmaceutical (F), Bayer AG (C), Clearside Biomedical, Inc (C), Clearside Biomedical, Inc (F), D.O.R.C. International (C), Genentech, Inc (C), Genentech, Inc (F), Novartis International AG (C), Novartis International AG (F), ONL Therapeutics, Inc (C), Ophthotech Corporation (F), Regeneron Pharmaceuticals, Inc (C), Regeneron Pharmaceuticals, Inc (F), Regenxbio Inc (C), Regenxbio Inc (F), Roche (C), Santen Inc (C); Srinivas Sadda, Allergan (C), Amgen (C), Carl Zeiss Meditec (F), Centervue (C), Centervue (F), Genentech/Roche (C), Heidelberg (C), Nidek (F), Novartis (C), Optos (C), Optos (F), Oxurion (C), Topcon (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5329. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Aditya Verma, Muneeswar Gupta Nittala, Swetha Bindu Velaga, Zhihong Hu, Brenda Zhou, Shaun Lampen, Michael S Ip, Charles Clifton Wykoff, Srinivas R Sadda; Correlation between retinal vessel density and retinal layer thickness in eyes with proliferative diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5329.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To investigate the correlation between retinal capillary vessel density (VD) and retinal layer thickness (RT) in the macular region of eyes with proliferative diabetic retinopathy (PDR) and no macular edema

Methods : 40 eyes of 40 subjects were enrolled in this prospective,randomised clinical trial (RECOVERY:NCT02863354) and 35 eyes with OCT angiography (OCTA) were included in this analysis. All eyes had treatment naive PDR with no macular edema. All subjects underwent spectral-domain optical coherence tomography (SD-OCT) [Spectralis Heidelberg Retinal Angiogram (HRA+OCT) scans (20 x 20 degrees; 512 x 97; ART = 5)] and OCTA using the RTVue-XR 100 Avanti (Optovue, Inc). Baseline (pre-treatment) images were included in the analysis. Superficial (nerve fiber plus ganglion cell layers) and deep (inner plexiform, inner nuclear, & outer plexiform layers) inner retinal layer thickness values were generated after manual segmentation of all the B scans using custom reading center software (3D-OCTOR) by certified graders. Capillary VD was generated (superficial and deep) using RTVue review software. Both RT and VD measurements were generated within the entire scan area for both superficial and deep retinal layers. A bivariate correlation analysis (Spearman’s) was performed between the corresponding RT values and the VD for the superficial and deep layers, respectively. Statistical analysis was performed using SPSS, a p value of < 0.05 was considered as statistically significant.

Results : Thirty five eyes of 35 subjects (3 males, 32 females) were included in this analysis. The thickness measurements (microns), in mean + SD were as follows: superficial RT (SRT), 78.7 + 13.3; deep RT (DRT), 106.7 + 14.7 and total RT, 286.2 + 27.9. The corresponding capillary perfusion values (%), in mean + SD were: superficial VD (SVD), 42 + 4 and deep VD (DVD), 49 + 4. There was no significant correlation between SRT and SVD (r = 0.29, p = 0.24); DRT and DVD (r = 0.41, p = 0.09; TRT and SVC (r = 0.18, p = 0.48); TRT and DVD (r = 0.25, p = 0.33).

Conclusions : No correlation was observed between retinal thickness and capillary perfusion in either the superficial or deep inner retinal layers in eyes with treatment naive PDR and no macular edema. This lack of correlation suggests that other compensatory mechanisms may influence retinal thickness in these eyes with PDR, despite alterations in perfusion.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×