July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Retinal Capillary Non-Perfusion Relationship to Arteries or Veins as Observed on Widefield Optical Coherence Tomography Angiography: A Pilot Study in Diabetic Retinopathy
Author Affiliations & Notes
  • Akihiro Ishibazawa
    New England Eye Center, Tufts Medical Center, Asahikawa, Hokkaido, Japan
    Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
  • Lucas R. De Pretto
    Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Boston, Massachusetts, United States
  • A. Yasin Alibhai
    New England Eye Center, Tufts Medical Center, Asahikawa, Hokkaido, Japan
  • Malvika Arya
    New England Eye Center, Tufts Medical Center, Asahikawa, Hokkaido, Japan
  • Osama Sorour
    New England Eye Center, Tufts Medical Center, Asahikawa, Hokkaido, Japan
  • Nihaal Mehta
    New England Eye Center, Tufts Medical Center, Asahikawa, Hokkaido, Japan
  • Eric Moult
    Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Boston, Massachusetts, United States
  • Caroline R Baumal
    New England Eye Center, Tufts Medical Center, Asahikawa, Hokkaido, Japan
  • Andre J. Witkin
    New England Eye Center, Tufts Medical Center, Asahikawa, Hokkaido, Japan
  • Akitoshi Yoshida
    Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
  • Jay S Duker
    New England Eye Center, Tufts Medical Center, Asahikawa, Hokkaido, Japan
  • James G Fujimoto
    Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Boston, Massachusetts, United States
  • Nadia K Waheed
    New England Eye Center, Tufts Medical Center, Asahikawa, Hokkaido, Japan
  • Footnotes
    Commercial Relationships   Akihiro Ishibazawa, Nidek Medical Products, Inc. (F), Topcon Medical Systems, Inc. (F); Lucas De Pretto, None; A. Yasin Alibhai, None; Malvika Arya, None; Osama Sorour, None; Nihaal Mehta, None; Eric Moult, None; Caroline Baumal, Carl Zeiss Meditec (F); Andre Witkin, None; Akitoshi Yoshida, Nidek Medical Products, Inc. (P), Tomey Corporation (P), Topcon Medical Systems, Inc. (P), Topcon Medical Systems, Inc. (F); Jay Duker, Carl Zeiss Meditec, Inc. (C), Carl Zeiss Meditec, Inc. (F), Optovue, Inc. (C), Optovue, Inc. (F), Topcon Medical Systems, Inc. (C), Topcon Medical Systems, Inc. (F); James Fujimoto, Carl Zeiss Meditec, Inc. (P), Optovue, Inc. (P), Optovue, Inc. (I), Optovue, Inc. (C), Topcon Medical Systems, Inc. (R); Nadia Waheed, Carl Zeiss Meditec, Inc. (F), Nidek Medical Products, Inc. (F), Optovue, Inc. (C), Topcon Medical Systems, Inc. (F)
  • Footnotes
    Support  Macula Vision Research Foundation (MVRF, Massachusetts Lions Clubs)
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5339. doi:https://doi.org/
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    • Get Citation

      Akihiro Ishibazawa, Lucas R. De Pretto, A. Yasin Alibhai, Malvika Arya, Osama Sorour, Nihaal Mehta, Eric Moult, Caroline R Baumal, Andre J. Witkin, Akitoshi Yoshida, Jay S Duker, James G Fujimoto, Nadia K Waheed; Retinal Capillary Non-Perfusion Relationship to Arteries or Veins as Observed on Widefield Optical Coherence Tomography Angiography: A Pilot Study in Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5339. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate whether retinal capillary non-perfusion is found predominantly adjacent to arteries or veins in eyes with diabetic retinopathy (DR).

Methods : 63 eyes from 44 patients with proliferative DR (PDR) or non-PDR (NPDR) were included. 12x12 mm foveal-centered optical coherence tomography (OCT) angiography (OCTA) images were taken using an SS-OCT (Plex Elite 9000). In 37 eyes, widefield montages with 5 fixation points were also obtained. A semi-automatic algorithm that detected non-perfusion in full-retina slabs was developed, and the percentages of capillary nonperfusion within the total image area were calculated. Retinal arteries and veins were manually traced. Based on the shortest distance, non-perfusion pixels were labelled as either arterial-side or venous-side. Arterial-adjacent and venous-adjacent non-perfusion, and the A/V ratio (arterial-adjacent non-perfusion divided by venous-adjacent non-perfusion) were quantified.

Results : 22 eyes with moderate NPDR, 16 eyes with severe NPDR, and 25 eyes with PDR were scanned. Total non-perfusion area in PDR (median: 8.93%) was greater (p < 0.01) than in moderate NPDR (3.49%). Arterial-adjacent non-perfusion was greater than venous-adjacent non-perfusion for all stages of DR (p < 0.001). The median A/V ratios were 1.93 in moderate NPDR, 1.84 in severe NPDR and 1.78 in PDR. The A/V ratio was negatively correlated with the total non-perfusion area (r = -0.600, p < 0.0001). The results from the widefield montages showed similar patterns: the median A/V ratio was 1.56 in moderate NPDR, 1.59 in severe NPDR and 1.42 in PDR. The A/V ratio for the montage images was also negatively correlated with the total non-perfusion (r = - 0.598, p< 0.0001).

Conclusions : In DR, earlier changes and smaller non-perfusion tends to be artery-adjacent, while later and larger non-perfusion extends towards veins.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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