July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Risk Factors for the Incidence of Uveitis in a National Medical Claims Database
Author Affiliations & Notes
  • Brian C Toy
    Ophthalmology, USC Roski Eye Institute, Los Angeles, California, United States
  • Youning Zhang
    Ophthalmology, USC Roski Eye Institute, Los Angeles, California, United States
  • Sarina Amin
    Ophthalmology, USC Roski Eye Institute, Los Angeles, California, United States
  • Narsing A Rao
    Ophthalmology, USC Roski Eye Institute, Los Angeles, California, United States
  • Khristina Ipapo
    Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, California, United States
  • Seth A Seabury
    Ophthalmology, USC Roski Eye Institute, Los Angeles, California, United States
    Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Brian Toy, Eleusis (C); Youning Zhang, None; Sarina Amin, None; Narsing Rao, None; Khristina Ipapo, None; Seth Seabury, Precision Health Economics (C)
  • Footnotes
    Support  Unrestricted Grant to the Department of Ophthalmology from Research to Prevent Blindness, New York, NY; P30EY029220 from NIH
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5482. doi:
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    • Get Citation

      Brian C Toy, Youning Zhang, Sarina Amin, Narsing A Rao, Khristina Ipapo, Seth A Seabury; Risk Factors for the Incidence of Uveitis in a National Medical Claims Database. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5482.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Prior studies evaluating risk factors for the development of uveitis and its complications have suggested a potential correlation between sex and race, among other factors. To study the real-world risk factors for development of uveitis, the present study employed analyses of data from a national health insurance claims database.

Methods : Medical claims and demographic data were obtained from OptumInsight Clinformatics Data Mart, a large, national medical claims database. Inclusion required continuous enrollment for at least 15 months within 2007 to 2015 (n=21,516,133). For inclusion in the uveitis sample, an eye care provider established the index uveitis diagnosis (index date). Patients with an index date within 3 months after incisional intraocular surgery were excluded (n=137,536). For non-uveitis patients, an index date was randomly selected from the individual’s enrollment period. We excluded those with an index date after September 30, 2014 to ensure ICD9 coding throughout the observation period. We compared chronic comorbidities and risk factors for uveitis employing multivariable logistic regression.

Results : Patients with uveitis were on average older than the full Optum population (52.8 vs. 40.4 years), less likely to be male (42.0% vs. 48.8%), more likely to be black (11.6% vs 8.6%), and less likely to be Hispanic (6.9% vs 10.2%) or Asian (3.6% vs. 4.4%) (p<0.01 for all differences). Logistic regression confirmed the unadjusted findings of higher incidence of uveitis among blacks (odds ratio (OR) compared to white, non-Hispanics: 1.32, p<0.01) and lower among males (OR 0.82, p<0.01) and Hispanics (0.88, p<0.01), but found higher incidence among Asians (OR 1.08, p<0.01). The five co-morbidities most strongly associated with uveitis incidence included rheumatoid arthritis (OR: 2.31, p<0.01), AIDS/HIV (OR: 2.19, p<0.01), hypertension (OR: 1.25, p<0.01), diabetes (OR: 1.16, p<0.01) and valvular disease (OR: 1.16, p<0.01). Income and education were positively associated with uveitis incidence.

Conclusions : The real-world incidence of uveitis differs according to sex and race, and is higher among individuals with many common chronic illnesses. Patients with higher socioeconomic status have higher diagnosed incidence, potentially reflecting differences in access to healthcare.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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