July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Annual rates of change of mRNFL, mGCIPL, and cpRNFL in various stages of glaucoma
Author Affiliations & Notes
  • Masayuki Inuzuka
    Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan, Gifu, Gifu, Japan
  • Akira Sawada
    Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan, Gifu, Gifu, Japan
  • Hiroko Inuzuka
    Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan, Gifu, Gifu, Japan
  • Tetsuya Yamamoto
    Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan, Gifu, Gifu, Japan
  • Footnotes
    Commercial Relationships   Masayuki Inuzuka, None; Akira Sawada, None; Hiroko Inuzuka, None; Tetsuya Yamamoto, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5526. doi:https://doi.org/
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      Masayuki Inuzuka, Akira Sawada, Hiroko Inuzuka, Tetsuya Yamamoto; Annual rates of change of mRNFL, mGCIPL, and cpRNFL in various stages of glaucoma. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5526. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To explore changes in the macula retinal nerve fiber layer (mRNFL), macular ganglion cell layer and inner plexiform layer (mGCIPL), and circumpapillary retinal nerve fiber layer (cpRNFL) in mild, moderate, and severe stages of normal tension glaucoma (NTG) using spectral domain optical coherence tomography.

Methods : We retrospectively examined 218 NTG eyes assigned to age-, refraction-, and intraocular pressure (IOP)-matched groups based on initial mean deviation (MD; Humphrey Field Analyzer program Central 30-2): mild (MD > -6 dB), moderate (-6 dB ≧ MD ≧-12 dB), and severe (-12 dB > MD >-20 dB). and calculated annual rates of change in mRNFL, mGCIPL, and cpRNFL thickness. Kruskal-Wallis test and Bonferroni correction were used for statistical analysis.

Results : There were no significant differences among the stages in terms of age, spherical equivalent refraction, or average IOP during the 6-year follow-up period. There were significant initial differences in mGCIPL, cpRNFL, and mRNFL among the three groups (P < 0.0001 in all 6 sectors, except for mRNFL in the superonasal sector). There were no significant differences in the rate of change for the mRNFL and mGCIPL among the groups in any of the 6 sectors. However, there was a significant difference in the rate of change of the cpRNFL among the groups (in all sectors: P < 0.0001).

Conclusions : Changes in the mRNFL and mGCIPL can reflect progression of NTG even in its advanced stage (MD >-20 dB). However, the implication of such changes in the cpRNFL may be less clear due to a floor effect in the advanced stage of glaucoma (MD >-20 dB).

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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