Abstract
Purpose :
To investigate the topographic relationship among focal lamina cribrosa (LC) defect, microvasculature dropout (MvD) and border tissue morphology in open angle glaucoma (OAG) eyes using spectral-domain (SD) optical coherence tomography (OCT).
Methods :
One hundred twenty-six OAG eyes and 97 normal eyes were included. The maximum externally oblique border tissue (EOBT) length was measured by using enhanced depth imaging SD-OCT as well as focal LC defect size. Circumferential MvD width and the MvD height ratio were measured using OCT angiography. We investigated whether there was a correlation among the locations of the parameters.
Results :
Focal LC defect location was correlated with MvD location (R = 0.62; P < .001). Maximum EOBT length location was also correlated with focal LC defect (R = 0.31; P = .037) and MvD (R = 0.33; P = .020). Multivariate logistic regression analysis demonstrated that a worse VF defect was significantly associated with the presence of focal LC defects and MvDs (P < .002 for focal LC defects, P =0.002 for MvDs). MvD circumferential width was associated with glaucoma severity (R = -0.66, P < .001), whereas focal LC defect size and MvD height ratio were associated with maximum EOBT length (R = 0.48, P < .001 for focal LC defect size; R = 0.65, P < .001 for MvD height ratio) and AL (R = 0.53, P < .001 for focal LC defect size; R = 0.52, P < .001 for MvD height ratio).
Conclusions :
There was a topographical correlation among the locations of focal LC defect, MvD and maximum border length. In addition, the presence of focal LC defect and MvD were also strongly associated with glaucoma severity. Thus, it is thought that focal LC defect and MvD may be biomarkers that reflect glaucoma severity especially at the location of maximum border tissue elongation.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.