July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Impact of Cataract on Repeatability of Measurements of Macular Inner Retinal Thickness with Spectral-domain Optical Coherence Tomography in Glaucoma eye
Author Affiliations & Notes
  • Daisuke Shiba
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Sayaka Adachi
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Eri Hirano
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Yuka Ota
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Takeshi Ono
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Kenya Yuki
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Kazuo Tsubota
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Daisuke Shiba, None; Sayaka Adachi, None; Eri Hirano, None; Yuka Ota, None; Takeshi Ono, None; Kenya Yuki, None; Kazuo Tsubota, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5582. doi:
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      Daisuke Shiba, Sayaka Adachi, Eri Hirano, Yuka Ota, Takeshi Ono, Kenya Yuki, Kazuo Tsubota; Impact of Cataract on Repeatability of Measurements of Macular Inner Retinal Thickness with Spectral-domain Optical Coherence Tomography in Glaucoma eye. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5582.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the impact of cataract on repeatability of the measurement of inner retinal thickness in the macular area of the glaucomatous eye using spectral-domain optical coherence tomography (SD-OCT). Higher repeatability is thought to be an advantage in detecting glaucoma progression.

Methods : We included primary open angle glaucoma patients with mean deviation value above -18dB in this prospective observational study. Patient with any other intraocular disorder except senile cataract or history of intraocular surgery except successful glaucoma surgery was excluded. If both eyes were eligible, one eye was randomly selected. Based on the existence of cataract, patients were divided into two groups: cataract group and clear lens group. All cases underwent ganglion cell complex (GCC) thickness volume measurements. The same GCC map measurements was repeated within 2 months. The SD-OCT (Nidek; RS-3000 Advance) used in this study can acquire a macular GCC thickness map from 128 B-scans consisted of 512 A-scans. From the GCC thickness map, mean GCC thicknesses were calculated in 2 areas, superior semicircle (SSC) area and inferior semi-circle (ISC) area with a radius of 10 degrees. The repeatability of GCC measurement with SD-OCT was evaluated by intra-class correlation coefficient (ICC).

Results : 91 glaucomatous eyes consisted of 50 clear lens eyes and 41 cataract eyes were enrolled in this study. In clear lens group, mean age, mean MD value of Humphry field analyzer and mean GCC thicknesses in SSC and ISC at first visit were 60.7 +/- 5.0, -5.3 +/- 5.0 dB, 85.3 +/- 11.2μm and 77.8 +/- 15.4μm. In cataract group, mean age, mean MD value of Humphry field analyzer and mean GCC thicknesses in SSC and ISC at first visit were 69.2 +/- 5.8, -7.3 +/- 5.8dB, 80.7 +/- 14.3μm and 75.1 +/- 15.8μm. ICCs [95% CI] of GCC thickness in clear lens group were 0.987 [0.978-0.993] in SSC and 0.986 [0.976-0.992] in ISC. In cataract group, ICCs [95% CI] of GCC thickness were 0.928 [0.869-0.961] in SSC and 0.910 [0.839-0.951] in ISC.

Conclusions : Repeatability of GCC thickness measurement with SD-OCT in cataract eye had statistically significantly lower repeatability than in eyes with clear lens.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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