July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
DIAGNOSTIC PERFORMANCE OF OPTIC NERVE HEAD HEMOGLOBIN LEVELS MEASUREMENT IN EYES WITH EARLY PRIMARY OPEN ANGLE GLAUCOMA
Author Affiliations & Notes
  • Carolina de Carvalho
    Glaucoma, Instituto dos Olhos Ciencias Medicas, Belo Horizonte, Minas Gerais, Brazil
    Glaucoma, Hospital Medicina dos Olhos, Osasco, Sao Paulo, Brazil
  • ANA SCORALICK
    Glaucoma, Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
    Glaucoma, Hospital Medicina dos Olhos, Osasco, Sao Paulo, Brazil
  • Diego Torres Dias
    Glaucoma, Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
    Glaucoma, Hospital Medicina dos Olhos, Osasco, Sao Paulo, Brazil
  • Carolina Gracitelli
    Glaucoma, Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Syril Dorairaj
    Glaucoma, Mayo Clinic, Jacksonville, Florida, United States
  • Augusto Paranhos
    Glaucoma, Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Fabio Kanadani
    Glaucoma, Instituto dos Olhos Ciencias Medicas, Belo Horizonte, Minas Gerais, Brazil
    Glaucoma, Mayo Clinic, Jacksonville, Florida, United States
  • Tiago Prata
    Glaucoma, Hospital Medicina dos Olhos, Osasco, Sao Paulo, Brazil
    Glaucoma, Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships   Carolina de Carvalho, None; ANA SCORALICK, None; Diego Dias, None; Carolina Gracitelli, None; Syril Dorairaj, None; Augusto Paranhos, None; Fabio Kanadani, None; Tiago Prata, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5611. doi:https://doi.org/
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      Carolina de Carvalho, ANA SCORALICK, Diego Torres Dias, Carolina Gracitelli, Syril Dorairaj, Augusto Paranhos, Fabio Kanadani, Tiago Prata; DIAGNOSTIC PERFORMANCE OF OPTIC NERVE HEAD HEMOGLOBIN LEVELS MEASUREMENT IN EYES WITH EARLY PRIMARY OPEN ANGLE GLAUCOMA. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5611. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : It has been suggested that patients with established glaucoma have lower levels of optic nerve head hemoglobin (ONH Hb). We sought to investigate the glaucoma discrimination ability of ONH Hb measurement as assessed by non-invasive automated colorimetric analysis (RetinaLyze®; RetinaLyze System A/S) in patients with early glaucoma.

Methods : A prospective, observational, cross-sectional study was carried-out, in which patients with early glaucoma (visual field mean deviation index [VFMD] ≥-6 dB) and healthy participants were consecutively enrolled. After inclusion, nonmydriatic color fundus photographs and peripapillary retinal nerve fiber layer (pRNFL) thickness measurements (through spectral-domain optical coherence tomography) were obtained from all participants. The software initially delineated the ONH border and identified the central retinal vessels. On the basis of colorimetric analysis, Hb levels were determined in the neuroretinal rim, cup and vessels. Eyes were then classified in glaucoma or not by the software automated algorithm, and sensitivity, specificity and accuracy values were determined.

Results : A total of 46 eyes from 46 patients were included (23 patients with glaucoma and 23 controls). Mean age of glaucomatous patients and controls were 60.4 and 54.4 years, respectively. Mean VFMD index of glaucomatous eyes was -2.1±2.9 dB. The program was unable to perform the analysis due to image-related issues in 2 eyes. Sensitivity and specificity values were 64% (95% CI, 40.7 – 82.8% and 91% (95% CI, 70.8 – 98.9%), respectively. Overall, the test yielded an accuracy of 77% (95 CI, 62 – 88%).

Conclusions : Our initial results suggest that although the software automated algorithm presents moderate sensitivity outcomes in this population with early stage glaucoma, it had a good diagnostic performance in the participants without the disease. Further analyses (larger sample) are warranted in order to confirm our initial findings and to investigate its applicability in a clinical setting.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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